{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:49:08Z","timestamp":1790372948865,"version":"4.1.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T00:00:00Z","timestamp":1573776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hosp Pharm"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>Background:Methicillin-resistant Staphylococcus aureus (MRSA) nasal polymerase chain reaction (PCR) testing can rapidly detect MRSA colonization via nasopharyngeal swab. With a high negative predictive value for MRSA pneumonia, this test may help minimize the duration of anti-MRSA therapy and associated adverse drug events. Objective: This study aimed to evaluate the impact of a pharmacist-initiated MRSA nasal PCR protocol on pneumonia therapy. Methods: This retrospective, quasi-experimental study evaluated adult patients with pneumonia before and after the implementation of a pharmacist-initiated MRSA nasal PCR protocol. The primary outcome of this study was to compare duration of anti-MRSA therapy between the Pre-PCR group and PCR group. Secondary comparisons included duration of antipseudomonal therapy, time from intravenous (IV) to oral interchange, and clinical outcomes. Results: In total, 210 patients (Pre-PCR: n = 138, PCR: n = 72) were included. The MRSA nasal PCR result was negative for 63 patients (87.5%), and 56 (88.9%) vancomycin orders were discontinued within 24 hours of the negative result. The mean duration of vancomycin therapy was significantly shorter in the PCR group (2.5 vs 1.4 days, P &lt; .001) as well as duration of IV therapy (5 vs 3.9 days, P = .003). There was no difference between groups in duration of antipseudomonal therapy ( P = .425), acute kidney injury (AKI; P = .332), 30-day readmission ( P = .137), or 30-day mortality ( P = .179). Conclusion and Relevance: A pharmacist-driven MRSA nasal PCR protocol significantly decreased the duration of anti-MRSA therapy and IV antibiotics in patients with pneumonia. These findings add to the relatively small body of literature supporting pharmacist-initiated rapid diagnostic testing and follow-up.<\/jats:p>","DOI":"10.1177\/0018578719888906","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T08:06:30Z","timestamp":1573805190000},"page":"221-227","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Impact of a Pharmacist-Driven MRSA Nasal PCR Protocol on Pneumonia Therapy"],"prefix":"10.1177","volume":"56","author":[{"given":"Selena N.","family":"Pham","sequence":"first","affiliation":[{"name":"Department of Pharmacy Services, Mercy Health Saint Mary\u2019s, Grand Rapids, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2767-8375","authenticated-orcid":false,"given":"Abby C.","family":"Sturm","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, Mercy Health Saint Mary\u2019s, Grand Rapids, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua S.","family":"Jacoby","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, Mercy Health Saint Mary\u2019s, Grand Rapids, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nnaemeka E.","family":"Egwuatu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Mercy Health Saint Mary\u2019 s, Grand Rapids, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa E.","family":"Dumkow","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, Mercy Health Saint Mary\u2019s, Grand Rapids, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,11,15]]},"reference":[{"key":"bibr1-0018578719888906","unstructured":"Pfuntner A, Wier LM, Stocks C. Most frequent conditions in U.S. Hospitals, 2011. HCUP Statistical Brief #162. Rockville, MD: Agency for Healthcare Research and Quality; 2013. http:\/\/www.hcup-us.ahrq.gov\/reports\/statbriefs\/sb162.pdf. Accessed November 1, 2019."},{"key":"bibr2-0018578719888906","unstructured":"National Center for Health Statistics (U.S.), Centers for Disease Control and Prevention (U.S.). Health, United States, 2012: With Special Features on Emergency Care. Hyattsville, MD: National Center for Health Statistics; 2013."},{"key":"bibr3-0018578719888906","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw353"},{"key":"bibr4-0018578719888906","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2016.11.014"},{"key":"bibr5-0018578719888906","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00041009"},{"key":"bibr6-0018578719888906","doi-asserted-by":"publisher","DOI":"10.1086\/511159"},{"issue":"2","key":"bibr7-0018578719888906","first-page":"107","volume":"70","author":"Rioux J","year":"2017","journal-title":"Can J Hosp Pharm"},{"key":"bibr8-0018578719888906","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-017-0764-7"},{"key":"bibr9-0018578719888906","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy024"},{"key":"bibr10-0018578719888906","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01805-13"},{"key":"bibr11-0018578719888906","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2016.08.011"},{"key":"bibr12-0018578719888906","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2016.11.008"},{"key":"bibr13-0018578719888906","doi-asserted-by":"publisher","DOI":"10.1177\/1060028018823027"},{"key":"bibr14-0018578719888906","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw118"},{"key":"bibr15-0018578719888906","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02432-16"},{"key":"bibr16-0018578719888906","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp160964"},{"key":"bibr17-0018578719888906","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-018-0647-3"}],"container-title":["Hospital Pharmacy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0018578719888906","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0018578719888906","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0018578719888906","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:39:02Z","timestamp":1777451942000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0018578719888906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,15]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1177\/0018578719888906"],"URL":"https:\/\/doi.org\/10.1177\/0018578719888906","relation":{},"ISSN":["0018-5787","1945-1253"],"issn-type":[{"value":"0018-5787","type":"print"},{"value":"1945-1253","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,15]]}}}