{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:20:28Z","timestamp":1777681228711,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hosp Pharm"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:p>Background: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare and life-threatening hypersensitivity reaction. It is characterized by fever, skin lesions, and internal organ involvement. Sorafenib is a tyrosine kinase inhibitor that is used for the treatment of certain cancers such as hepatocellular, renal cell, and thyroid cancer. Case Presentation: The case is a 40\u2009years old man who presented with fever, generalized skin rash, and pruritus. The patient has received sorafenib for the treatment of medullary thyroid cancer (MTC) from 3\u2009weeks ago. Following presentation, the drug was discontinued and causality was assessed by scoring system RegiSCAR and Naranjo scale that showed a probable DRESS. There was no internal organ involvement based on the laboratory evaluations. The considerable abnormality was eosinophilia among patient\u2019s laboratory tests. Antihistamines and topical and systemic corticosteroids were utilized for the management of the symptoms. Conclusion: To the best of our knowledge, this is the first case report of DRESS syndrome by sorafenib in the patients with MTC. Clinicians should be aware of sign and symptoms suggesting DRESS syndrome of sorafenib.<\/jats:p>","DOI":"10.1177\/0018578720946764","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T04:04:36Z","timestamp":1595822676000},"page":"646-649","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["DRESS Syndrome Induced by Sorafenib in a Patient With Medullary Thyroid Cancer: A Case Report"],"prefix":"10.1177","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5814-9703","authenticated-orcid":false,"given":"Hamid","family":"Rahmani","sequence":"first","affiliation":[{"name":"Department of pharmacotherapy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niayesh","family":"Mohebbi","sequence":"additional","affiliation":[{"name":"Department of pharmacotherapy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayed Mahmoud","family":"Sajjadi-Jazi","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism Research Center, Endocrinology and Metabolism sciences institute, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,7,27]]},"reference":[{"key":"bibr1-0018578720946764","unstructured":"Mackenhaupt M. (2020). Drug reaction with eosinophilia and systemic symptom. Corona R, ed. Up To Date. https:\/\/www.uptodate.com\/contents\/drug-reaction-with-eosinophilia-and-systemic-symptoms-dress. Accessed June 25, 2020."},{"key":"bibr2-0018578720946764","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18061243"},{"key":"bibr3-0018578720946764","doi-asserted-by":"publisher","DOI":"10.1111\/all.12350"},{"key":"bibr4-0018578720946764","unstructured":"Sherman SI. (2019). Differentiated thyroid cancer refractory to standard treatment: chemotherapy. Mulder JE, ed. Up To Date. https:\/\/www.uptodate.com\/contents\/differentiated-thyroid-cancer-refractory-to-standard-treatment-chemotherapy. Accessed June 25, 2020."},{"key":"bibr5-0018578720946764","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.0068"},{"key":"bibr6-0018578720946764","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0621"},{"key":"bibr7-0018578720946764","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1262836"},{"key":"bibr8-0018578720946764","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0334"},{"key":"bibr9-0018578720946764","doi-asserted-by":"publisher","DOI":"10.1055\/s-0044-100378"},{"key":"bibr10-0018578720946764","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"bibr11-0018578720946764","doi-asserted-by":"publisher","DOI":"10.4166\/kjg.2016.67.6.337"},{"issue":"5","key":"bibr12-0018578720946764","first-page":"468","volume":"18","author":"Salame N","year":"2019","journal-title":"J Drugs Dermatol"}],"container-title":["Hospital Pharmacy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0018578720946764","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0018578720946764","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0018578720946764","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:39:21Z","timestamp":1777451961000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0018578720946764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,27]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1177\/0018578720946764"],"URL":"https:\/\/doi.org\/10.1177\/0018578720946764","relation":{},"ISSN":["0018-5787","1945-1253"],"issn-type":[{"value":"0018-5787","type":"print"},{"value":"1945-1253","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,27]]}}}