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Its association with agranulocytosis is even rarer, with fewer than 10 cases describing the coexistence of DRESS with agranulocytosis reported in the English literature. Case Summary: An otherwise well 40-year-old female presented with a sore throat and cervical lymphadenopathy, with investigations revealing DRESS and agranulocytosis secondary to carbamazepine. Conclusion: DRESS and agranulocytosis are serious, potentially life-threatening adverse drug reactions which can initially present as cervical lymphadenopathy. As carbamazepine is considered first-line therapy for certain chronic neuropathic conditions such as trigeminal neuralgia, clinicians should be aware of the varying clinical presentations of both conditions.<\/jats:p>","DOI":"10.1177\/0018578721990899","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T01:25:25Z","timestamp":1611797125000},"page":"130-134","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Drug Reaction with Eosinophilia and Systemic Symptoms and Agranulocytosis Presenting as Cervical Lymphadenopathy"],"prefix":"10.1177","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6832-6184","authenticated-orcid":false,"given":"Laura","family":"Chen","sequence":"first","affiliation":[{"name":"Monash Health, Clayton, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemente","family":"Chia","sequence":"additional","affiliation":[{"name":"Monash Health, Clayton, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anik","family":"Saha","sequence":"additional","affiliation":[{"name":"Monash Health, Clayton, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,1,27]]},"reference":[{"issue":"6","key":"bibr1-0018578721990899","first-page":"31","volume":"6","author":"Choudhary S","year":"2013","journal-title":"J Clin Aesthet Dermatol"},{"key":"bibr2-0018578721990899","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13683"},{"key":"bibr3-0018578721990899","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07284.x"},{"key":"bibr4-0018578721990899","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.913748"},{"key":"bibr5-0018578721990899","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2010.03832.x"},{"key":"bibr6-0018578721990899","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-015-0107-2"},{"issue":"6","key":"bibr7-0018578721990899","first-page":"842","volume":"96","author":"Kato M","year":"2016","journal-title":"Acta Derm Venereol"},{"key":"bibr8-0018578721990899","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.3033"},{"key":"bibr9-0018578721990899","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2008.07.014"},{"key":"bibr10-0018578721990899","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07704.x"},{"key":"bibr11-0018578721990899","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.55.1"},{"key":"bibr12-0018578721990899","doi-asserted-by":"publisher","DOI":"10.4088\/PCC.v08n0510a"},{"key":"bibr13-0018578721990899","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e3282f15fb9"},{"key":"bibr14-0018578721990899","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.01.017"},{"key":"bibr15-0018578721990899","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v7.i6.705"},{"issue":"2","key":"bibr16-0018578721990899","first-page":"139","volume":"16","author":"Shiohara T","year":"2017","journal-title":"Expert Opin Drug Saf"},{"key":"bibr17-0018578721990899","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"bibr18-0018578721990899","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2016.03.006"}],"container-title":["Hospital Pharmacy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0018578721990899","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0018578721990899","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0018578721990899","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:39:47Z","timestamp":1777451987000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0018578721990899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,27]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1177\/0018578721990899"],"URL":"https:\/\/doi.org\/10.1177\/0018578721990899","relation":{},"ISSN":["0018-5787","1945-1253"],"issn-type":[{"value":"0018-5787","type":"print"},{"value":"1945-1253","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,27]]}}}