{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:24:58Z","timestamp":1777681498291,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hosp Pharm"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:p>Background: Monitoring of vancomycin using the area under the curve (AUC) to minimum inhibitory concentration (MIC) ratio is now preferred for serious methicillin-resistant Staphylococcus aureus infections. Vancomycin AUC\/MIC monitoring is being investigated but is not yet well elucidated with other bacterial pathogens. Methods: A retrospective cross-sectional study was conducted assessing patients with streptococcal bacteremia treated with vancomycin definitive therapy. AUC was calculated using a Bayesian approach, and classification and regression tree analysis was used to identify a vancomycin AUC threshold predictive of clinical failure. Results: Eleven patients had a vancomycin AUC\u2009&lt;\u2009329 of which 8 (73%) experienced clinical failure, while 35 patients had a vancomycin AUC\u2009\u2265\u2009329 of which 12 (34%) experienced clinical failure ( P\u2009=\u2009.04). Hospital length of stay was longer in the AUC\u2009\u2265\u2009329 group (15 vs 8\u2009days, P\u2009=\u2009.05), whereas time to bacteremia clearance (29 [22-45] vs 25 [20-29]\u2009hours, P\u2009=\u2009.15) and toxicity incidence (13% vs 4%, P\u2009=\u20091) were similar between groups. Conclusions: This study identified a VAN AUC threshold of &lt;329 to be predictive of clinical failure in patients with streptococcal bacteremia which should be interpreted as hypothesis-generating. Studies evaluating VAN AUC-based monitoring for streptococcal bloodstream infections along with other infection types are needed before implementation into clinical practice can be recommended.<\/jats:p>","DOI":"10.1177\/00185787221139424","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T07:55:41Z","timestamp":1669881341000},"page":"289-294","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Vancomycin AUC and Clinical Failure in Patients with Streptococcal Bacteremia"],"prefix":"10.1177","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3787-9296","authenticated-orcid":false,"given":"Anna","family":"Aycock","sequence":"first","affiliation":[{"name":"The Ohio State University Wexner Medical Center, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica M.","family":"Smith","sequence":"additional","affiliation":[{"name":"The Ohio State University Wexner Medical Center, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelci","family":"Coe","sequence":"additional","affiliation":[{"name":"The Ohio State University Wexner Medical Center, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Hua","family":"Wang","sequence":"additional","affiliation":[{"name":"The Ohio State University Wexner Medical Center, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4382-7799","authenticated-orcid":false,"given":"Erica","family":"Reed","sequence":"additional","affiliation":[{"name":"The Ohio State University Wexner Medical Center, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,11,30]]},"reference":[{"key":"bibr1-00185787221139424","unstructured":"Centers for Disease Control and Prevention. 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