{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T12:01:31Z","timestamp":1784548891403,"version":"3.55.0"},"reference-count":10,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hosp Pharm"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:p>Naloxone, an opioid receptor antagonist, effectively reverses opioid overdose and opioid-induced respiratory depression. A few side effects were reported after naloxone administration, including arrhythmia and pulmonary edema. Although rare, naloxone-induced pulmonary edema can be a severe and sometimes life-threatening complication requiring mechanical ventilation. This condition is predominantly linked to an upsurge in catecholamines after opioid reversal as part of acute withdrawal syndrome, especially seen in patients who chronically use opioids. In this report, we present a case of a 66-year-old patient who developed pulmonary edema following the administration of multiple doses of intravenous and intranasal naloxone for opioid overdose. This case highlights the potential adverse effects associated with naloxone use and discusses how to employ this life-saving medication with minimal side effects.<\/jats:p>","DOI":"10.1177\/00185787241230074","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T07:05:50Z","timestamp":1707980750000},"page":"407-410","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["From Friend to Foe: A Case of Naloxone-Induced Pulmonary Edema"],"prefix":"10.1177","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3942-0173","authenticated-orcid":false,"given":"Ruba","family":"Ghalayni","sequence":"first","affiliation":[{"name":"Northwestern Medicine McHenry Hospital, McHenry, IL, USA"},{"name":"RFUMS, North Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3731-6717","authenticated-orcid":false,"given":"Bilal","family":"Al Kalaji","sequence":"additional","affiliation":[{"name":"Northwestern Medicine McHenry Hospital, McHenry, IL, USA"},{"name":"RFUMS, North Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Komal","family":"Malik","sequence":"additional","affiliation":[{"name":"Northwestern Medicine McHenry Hospital, McHenry, IL, USA"},{"name":"RFUMS, North Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,2,15]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"U.S Department of Health and Human Services. U.S. Surgeon General\u2019s advisory on naloxone and opioid overdose. published April 8 2022 Accessed September 25 2023. https:\/\/www.hhs.gov\/surgeongeneral\/reports-and-publications\/addiction-and-substance-misuse\/advisory-on-naloxone\/index.html"},{"key":"e_1_3_3_3_2","unstructured":"National Institute on Drug Abuse. Drug overdose death rates. 2023. Accessed October 25 2023. https:\/\/nida.nih.gov\/research-topics\/trends-statistics\/overdose-death-rates"},{"key":"e_1_3_3_4_2","unstructured":"U.S. Food and Drug Administration. Drug label Information: Naloxone. Published 2010. Accessed September 25 2023. https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2015\/208411lbl.pdf"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/2042098617744161"},{"key":"e_1_3_3_6_2","volume-title":"StatPearls","author":"Clark SB","year":"2022","unstructured":"Clark SB, Soos MP. Noncardiogenic pulmonary edema. In: StatPearls. StatPearls Publishing; October 31, 2022."},{"issue":"2","key":"e_1_3_3_7_2","first-page":"155","article-title":"Pulmonary edema: pathophysiology and diagnosis","volume":"15","author":"Murray JF.","year":"2011","unstructured":"Murray JF. Pulmonary edema: pathophysiology and diagnosis. Int J Tuberc Lung Dis. 2011;15(2):155-160.","journal-title":"Int J Tuberc Lung Dis"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0196-0644(05)80933-3"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/emp2.12740"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.929412"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/20009666.2020.1854417"}],"container-title":["Hospital Pharmacy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00185787241230074","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00185787241230074","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00185787241230074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:02:59Z","timestamp":1784545379000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00185787241230074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,15]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1177\/00185787241230074"],"URL":"https:\/\/doi.org\/10.1177\/00185787241230074","relation":{},"ISSN":["0018-5787","1945-1253"],"issn-type":[{"value":"0018-5787","type":"print"},{"value":"1945-1253","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,15]]}}}