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Donepezil is a reversible and specific acetylcholinesterase inhibitor, while memantine is an NMDA receptor antagonist which modulates glutamatergic activity. Although these medications are safe, they are associated with adverse effects, and cardiovascular complications are rare. The reported cardiac adverse drug reactions include bradycardia, atrioventricular block, and prolonged QT interval. We are reporting a case of an 81-year-old male patient with schizophrenia, Alzheimer\u2019s disease and bilateral sensorineural deafness receiving oral donepezil and memantine presented with second-degree atrioventricular block. The patient\u2019s atrioventricular block recovered completely in 2 to 3\u2009weeks after the discontinuation of donepezil-memantine and with a short course of sympathomimetic drugs.<\/jats:p>","DOI":"10.1177\/00185787241287368","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T02:17:08Z","timestamp":1729822628000},"page":"124-131","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Donepezil and Memantine-Induced Second-Degree Atrioventricular Block: A Case Report"],"prefix":"10.1177","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8710-2397","authenticated-orcid":false,"given":"Manjappa","family":"Mahadevappa","sequence":"first","affiliation":[{"name":"Department of Cardiology JSS Medical College &amp; Hospital, JSS Academy of Higher Education and Research, Mysore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6734-1334","authenticated-orcid":false,"given":"Sakeer","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2750-3711","authenticated-orcid":false,"given":"Shivananda","family":"Manohar","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, JSS Medical College &amp; Hospital, JSS Academy of Higher Education and Research, Mysore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"Alzheimer\u2019s disease: causes symptoms treatment & stages. https:\/\/my.clevelandclinic.org\/health\/diseases\/9164-alzheimers-disease"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/emj.2006.036251"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1871-5125(10)35003-5"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-024-04454-x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcgg.2016.01.002"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-014-0161-z"},{"key":"e_1_3_3_8_2","unstructured":"Kashou A Goyal A Nguyen T Ahmed I Chhabra L. 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