{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T12:01:42Z","timestamp":1784548902230,"version":"3.55.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hosp Pharm"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>\n                    <jats:bold>Objectives:<\/jats:bold>\n                    A commonly applied analgesic therapy for patients with severe abdominal pain due to cancer-related pain in the upper abdomen, is coeliac plexus neurolysis (CPN). Herein, a combination product of phenol and an iodine contrast agent are injected simultaneously. The chemical stability of such a combination product is unknown, and no chromatographic method is yet available that describes the simultaneous quantification of phenol and iomeprol. The aim of this study was to develop and validate a stability-indicating UPLC method for the simultaneous quantification of both phenol and iomeprol and to determine the chemical stability of a sterile 100\u2009mg\/mL phenol in 350\u2009mg\u2009I\/mL iomeprol solution for injection during shelf life.\n                    <jats:bold>Methods:<\/jats:bold>\n                    The product was compounded and sterilized in a GMP certified facility. The pharmaceutical analysis was validated by determination of the accuracy, precision, specificity, selectivity, carry-over and linearity. Pharmaceutical product stability was determined before and after sterilization, and during shelf life of 36\u2009months at 25\u00b0C\u2009\u00b1\u20092\u00b0C.\n                    <jats:bold>Results:<\/jats:bold>\n                    The accuracy for phenol and iomeprol was 97.1% to 99.3% and 100.0% to 100.2%, respectively. The RSD for repeatability and reproducibility for phenol were 0.65% and 1.17%, and for iomeprol 0.61% and 1.49%, respectively. All other tested parameters met the predefined validation criteria. All concentrations at all tested time points remained within \u00b12% of the initial concentrations for phenol and \u00b14% for iomeprol. No additional peaks were visible on the chromatograms.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    A stability-indicating method for the simultaneous quantification of phenol and iomeprol in a parental pharmaceutical preparation was developed and validated. This method was used to demonstrate the chemical stability of a newly developed sterile solution of 100\u2009mg\/mL phenol and 350\u2009mg\u2009I\/mL iomeprol. Chemical product stability was demonstrated during shelf life of up to 36\u2009months.\n                  <\/jats:p>","DOI":"10.1177\/00185787241289023","type":"journal-article","created":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T02:02:10Z","timestamp":1729303330000},"page":"146-153","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Validation of an UPLC-PDA Method for the Simultaneous Quantification of Phenol and Iomeprol in a Sterile Parenteral Preparation Used for Coeliac Plexus Block, and Its Application to a Pharmaceutical Stability Study"],"prefix":"10.1177","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6990-920X","authenticated-orcid":false,"given":"Sjoerd D.","family":"Meenks","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne (J.) A.","family":"Drost-Wijnne","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph A. C.","family":"van Wezel","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans (J.) A.","family":"van Suijlekom","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Catharina Hospital, Eindhoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willemijn","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne A. L.","family":"Rutgers","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mieke W.","family":"de Blois","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4389-6420","authenticated-orcid":false,"given":"Maarten J.","family":"Deenen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, The Netherlands"},{"name":"Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,18]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.giec.2018.06.004"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.36076\/ppj\/2019.19.281"},{"key":"e_1_3_2_4_2","volume-title":"StatPearls","author":"D\u2019Souza RS","year":"2023","unstructured":"D\u2019Souza RS, Warner NS. Phenol nerve block. In: StatPearls [Internet]. Treasure Island, FL: StatPearls Publishing; 2023."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1533-2500.2011.00490.x"},{"key":"e_1_3_2_6_2","first-page":"680","volume-title":"Practical Pharmaceutics\u2014An International Guideline for the Preparation Care and Use of Medicinal Products","author":"Bouwman-Boer Y","year":"2015","unstructured":"Bouwman-Boer Y, Fenton-May V, Le Brun P, eds. Practical Pharmaceutics\u2014An International Guideline for the Preparation Care and Use of Medicinal Products. 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