{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:31:40Z","timestamp":1777681900023,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hosp Pharm"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Pharmacokinetic and pharmacodynamic optimization of \u03b2-lactams, including meropenem, using extended infusion are recommended by contemporary guidance to overcome elevated MICs and high interpatient pharmacokinetic variability associated with severe illness. Logistical challenges including drug stability must be considered when employing extended infusion meropenem. Although meropenem stability has been determined in a variety of settings to allow for extended infusion, confirmation for use of ready to use dispensing devices would be of interest. The purpose of this study was to assess meropenem concentrations using commercially available 2\u2009g vials when diluted in 100\u2009mL normal saline prepared via addEASE connectors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Five replicate bags were prepared and sampled at 0, 1, 2, 3, 4, 5, and 6\u2009hours. Samples were stored frozen at ~\u221270\u00baC until meropenem concentrations determination using validated HPLC-UV and LC-MS\/MS methods. Stability was defined as &gt;90% recovery at the individual time point relative to the 0-hour concentration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Starting concentrations were similar across all five replicates with an average (range) of 21.2 (20.2-21.9) and 19.4\u2009mg\/mL (17.7-20.5\u2009mg\/mL) for HPLC-UV and LC\/MS-MS, respectively. No time point resulted in &lt; 90% meropenem recovery from the starting concentration as determined by either assay method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These data demonstrated meropenem concentrations using 2\u2009g vials diluted in 100\u2009mL normal saline when prepared using addEASE connectors remained &gt;90% of the initial concentration over 6\u2009hours at room temperature. This supports extended infusion administration of meropenem per contemporary guidance when prepared using this methodology. Since this method allows storage of doses in automated dispensing cabinets and bedside preparation, this may streamline pharmacy workflows and potentially reduce time to administration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00185787251381562","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T05:55:49Z","timestamp":1759989349000},"page":"171-175","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of Meropenem Stability in Meropenem Admixtures Using 2\u2009g Vials and Normal Saline Prepared Using addEASE\n                    <sup>\u00ae<\/sup>\n                    Connectors"],"prefix":"10.1177","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3606-0761","authenticated-orcid":false,"given":"Christian M.","family":"Gill","sequence":"first","affiliation":[{"name":"SSM Health Saint Louis University Hospital, MO, USA"},{"name":"Penn Presbyterian Medical Center, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Sierra","sequence":"additional","affiliation":[{"name":"University of Rhode Island, Kingston, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Kovarik","sequence":"additional","affiliation":[{"name":"SSM Health Saint Louis University Hospital, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Mays","sequence":"additional","affiliation":[{"name":"SSM Health Saint Louis University Hospital, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4842-3381","authenticated-orcid":false,"given":"Thomas","family":"Lavoie","sequence":"additional","affiliation":[{"name":"University of Rhode Island, Kingston, RI, USA"},{"name":"Providence Veterans Affairs Medical Center, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2595-5626","authenticated-orcid":false,"given":"Brahim","family":"Achour","sequence":"additional","affiliation":[{"name":"University of Rhode Island, Kingston, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0091270003257225"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2009.02.014"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2842"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciae403"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/1178636118804549"},{"key":"e_1_3_3_7_2","unstructured":"Meropenem [package insert]. AstraZeneca Pharmaceuticals LP; 1996."},{"key":"e_1_3_3_8_2","unstructured":"addEASE\u00ae 412040 Binary Connector. Accessed May 30 2024. https:\/\/www.bbraunusa.com\/en\/products\/b5\/addease-412040-binaryconnector.html"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/bmaa041"},{"key":"e_1_3_3_10_2","unstructured":"Meropenem [package insert]. Fresenius Kabi USA LLC; 1996."},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkae432"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01867-1"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/54.4.412"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/0018578718779009"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0149-2918(04)90051-3"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S212052"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02064-23"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1310\/hpj5004-296"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp060191"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.37573\/9781585286720.PT1001"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10060715"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/00185787231206525"}],"container-title":["Hospital Pharmacy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00185787251381562","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00185787251381562","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00185787251381562","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:41:20Z","timestamp":1777452080000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00185787251381562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,8]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1177\/00185787251381562"],"URL":"https:\/\/doi.org\/10.1177\/00185787251381562","relation":{},"ISSN":["0018-5787","1945-1253"],"issn-type":[{"value":"0018-5787","type":"print"},{"value":"1945-1253","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,8]]}}}