{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:31:50Z","timestamp":1777681910762,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"prisma health grant in aid","award":["no number associated with grant in aid. contact in"],"award-info":[{"award-number":["no number associated with grant in aid. contact in"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hosp Pharm"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Although 2019 EACTS Guidelines on Cardiopulmonary Bypass in Adult Cardiac Surgery recommend against routine use of prophylactic corticosteroids, perioperative glucocorticoids are still often used to mitigate hypotension, cardiac arrhythmias and respiratory failure following surgery with cardiopulmonary bypass (CPB). Limited data exists on safety and efficacy of intravenous (IV) hydrocortisone in this setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To assess the impact of intravenous hydrocortisone on postoperative complications after on-pump coronary artery bypass grafting (CABG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a single-center, retrospective chart review between 2021 and 2023. Adult patients with on-pump CABG requiring vasopressor therapy postoperatively were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of 153 patients included, 39 received IV hydrocortisone and 114 did not. The hydrocortisone group had significantly lower cortisol levels (15.8\u2009mcg\/dL vs 23.9\u2009mcg\/dL,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and higher incidence of a past medical history of atrial fibrillation (23.1% vs 2.6%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001) compared to the control group. Rates of postoperative atrial fibrillation (POAF) were similar between groups with 23.1% in the hydrocortisone group and 21.9% in the control group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.88), which maintained after controlling for age, history of atrial fibrillation, sex, and propensity score (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.86). Mean cumulative norepinephrine equivalents (NEE) were similar between hydrocortisone group and control (10.4\u2009mcg\/min vs 8.9\u2009mcg\/min,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.12). Hydrocortisone administration was associated with longer durations of vasopressor therapy (45.8 vs 28.9\u2009hours,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.001), insulin therapy (149.4 vs 82.2\u2009hours,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.003), and total mechanical ventilation time (59.3 vs 19.4 hours,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.049). There were no differences in surgical site infections between the hydrocortisone group versus control group (5.2% vs 5.2%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20091.00), including both non-infectious (2.6% vs 2.6%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20091.00) and infectious surgical site complications (2.6% vs 2.6%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20091.00).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>After controlling for sex, age, history of atrial fibrillation\/flutter, and propensity score, there was no significant association between the administration of IV hydrocortisone and POAF in patients receiving vasopressor support following on-pump CABG. Further prospective studies are needed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00185787251381597","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:52:08Z","timestamp":1765975928000},"page":"184-189","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Intravenous Hydrocortisone on Postoperative Atrial Fibrillation and Outcomes in Patients Receiving Vasopressor Support Following On-Pump Coronary Artery Bypass Grafting"],"prefix":"10.1177","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5789-0976","authenticated-orcid":false,"given":"Emma","family":"Paytes","sequence":"first","affiliation":[{"name":"Cone Health, Greensboro, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2144-2724","authenticated-orcid":false,"given":"Breanne","family":"Mefford","sequence":"additional","affiliation":[{"name":"Prisma Health Richland Hospital, Columbia, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9221-9143","authenticated-orcid":false,"given":"Bryan","family":"Love","sequence":"additional","affiliation":[{"name":"University of South Carolina, Columbia, SC, USA"},{"name":"Center for Outcomes Research and Evaluation, Columbia, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9202-1655","authenticated-orcid":false,"given":"Arran","family":"Amick","sequence":"additional","affiliation":[{"name":"Prisma Health Richland Hospital, Columbia, SC, USA"},{"name":"University of South Carolina, Columbia, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7516-4590","authenticated-orcid":false,"given":"Jenna","family":"Cox","sequence":"additional","affiliation":[{"name":"Prisma Health Richland Hospital, Columbia, SC, USA"},{"name":"University of South Carolina, Columbia, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/02676591221106324"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00273-1"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.14144"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2017.10.025"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezz267"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2020.11.002"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.89"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002737"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2018.04.014"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.7.862"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa071366"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000186370.78639.23"}],"container-title":["Hospital Pharmacy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00185787251381597","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00185787251381597","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00185787251381597","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:41:21Z","timestamp":1777452081000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00185787251381597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,17]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1177\/00185787251381597"],"URL":"https:\/\/doi.org\/10.1177\/00185787251381597","relation":{},"ISSN":["0018-5787","1945-1253"],"issn-type":[{"value":"0018-5787","type":"print"},{"value":"1945-1253","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,17]]}}}