{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T11:07:08Z","timestamp":1779016028117,"version":"3.51.4"},"reference-count":48,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hosp Pharm"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Traditional estimations of kidney function relying on serum creatinine (SCr) have significant limitations, as SCr is affected by many non-kidney determinants, such as body composition, age, nutritional status, volume status, etc. While cystatin C (cysC) is not without its own limitations, support for cysC use as an alternative or additional method of kidney function assessment is developing. The role of cysC-based estimations of kidney function in acutely ill, hospitalized patients has not been fully established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The objective of this study was to determine the incidence of discordance in estimated glomerular filtration rate (eGFR) between SCr-based calculations and SCr\/cysC-based calculations of kidney function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a single-center, retrospective, observational cohort study at an academic medical center including adult inpatients admitted in 2023 with SCr and CysC ordered. The primary outcome was discordance, defined as an occurrence of a 30% or greater difference between Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) eGFR SCr-cysC (eGFRcr-cys) and Cockcroft Gault (CG). Data was collected via chart review. Descriptive statistics were used. Nominal data (%) was analyzed by Fisher\u2019s exact test and continuous data (median [IQR]), including discordance, was analyzed via Wilcoxon matched pair signed ranked sum. For comparison, eGFRcr-cys was individualized for patients\u2019 body surface area.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The study included 463 patients (49% female, age 61 [48-72] years, 50.1% critically ill) with SCr 1.14 [0.68-1.82] mg\/dL and cysC 2.00 [1.33-2.78] g\/dL. Clearance was 60.0 [34.0-100.5] mL\/min by CG and 43.0 [24.5-71.0] mL\/min by eGFRcr-cys. Discordance rate was 44.3% (205\/463). Compared to patients without discordance, patients with discordance were younger (55\u2009years [44-65] vs 65\u2009years [55-74];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001) and had lower median SCr (0.93\u2009mg\/dL [0.48-1.58] vs 1.35\u2009mg\/dL [0.85-2.10],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001). Discordance occurred more often in critically ill patients (52.2%; 121\/232 patients) than general medicine\/surgical patients (36.4%; 84\/231 patients,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In hospitalized patients, eGFRcr-cys was discordant with CG in 44.3% of the population. Discordance in kidney function estimates likely impacts clinical care, including drug dosing. Further studies are needed to determine optimal use of each estimation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00185787251390769","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:11:01Z","timestamp":1763464261000},"page":"249-256","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Discordance Between Serum Creatinine-Based and Combined Serum Creatinine\/Cystatin C-Based Estimations of Kidney Function in Acutely Ill, Hospitalized Patients"],"prefix":"10.1177","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3439-0137","authenticated-orcid":false,"given":"Victoria L.","family":"Williams","sequence":"first","affiliation":[{"name":"The Ohio State University College of Pharmacy, Columbus, OH, USA"},{"name":"The Ohio State University Wexner Medical Center, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5631-4218","authenticated-orcid":false,"given":"Anthony T.","family":"Gerlach","sequence":"additional","affiliation":[{"name":"The Ohio State University College of Pharmacy, Columbus, OH, USA"},{"name":"The Ohio State University Wexner Medical Center, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"issue":"11","key":"e_1_3_4_2_2","first-page":"687","article-title":"Acute kidney injury: diagnosis and management","volume":"100","author":"Mercado MG","year":"2019","unstructured":"Mercado MG, Smith DK, Guard EL. 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