{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:02:58Z","timestamp":1789718578218,"version":"4.0.1"},"reference-count":21,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:00:00Z","timestamp":1771632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hosp Pharm"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Data comparing clinical outcomes of different intravenous iron products is limited. The purpose of this study was to compare the efficacy and safety of iron sucrose (IS) and ferric carboxymaltose (FCM) on hemoglobin levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This retrospective study was conducted at our quaternary care hospital between May 2015 and June 2019. Adults who received either of the study drugs were included in the analysis. Only the first encounter was used for patients who received multiple iron courses. Wilcoxon signed-rank test was used to compare outcomes versus baseline medians in each group separately, while Mann-Whitney\n                      <jats:italic toggle=\"yes\">U<\/jats:italic>\n                      test was used to compare the change between baseline and outcome medians between both groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 643 patients were included in the analysis, with 311 receiving iron sucrose (IS) and 332 receiving ferric carboxymaltose (FCM). The median Charlson Comorbidity Index (CCI) was 1 (0-5) for IS and 4 (0-7) for FCM (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001). Both iron products significantly increased hemoglobin levels by the end of the study compared to baseline, from 93 (84-105) to 114 (99-127) g\/L (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001) in the IS group and from 92 (81-103) to 103 (87-117) g\/L (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001) in the FCM group. Additionally, the change in hemoglobin was significantly more pronounced with IS 16.5 (5-29) g\/L versus 6.5 (\u22121 to 21) g\/L for FCM (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001). Stepwise multivariable linear regression analysis revealed that baseline hemoglobin [\u03b2\u2009=\u20090.52 (0.4-0.6);\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001], erythrocyte stimulating agents use [\u03b2\u2009=\u2009\u22127.4 (\u221211 to \u22123.8);\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001], total iron product dose [\u03b2\u2009=\u20090.01 (0.01-0.02);\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001], blood transfusion [\u03b2\u2009=\u2009\u22129.5 (\u221212 to \u22126.6);\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001], CCI [\u03b2\u2009=\u2009\u22120.6 (\u22121 to \u22120.12);\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.013], and FCM [\u03b2\u2009=\u2009\u22129.5 (\u221212 to \u22126.6);\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001] were the main predictors of hemoglobin level at the end of the study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Multiple factors were shown to affect hemoglobin levels, which need to be considered when managing anemia, including the type of iron formulation used. Our findings need to be verified in larger prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00185787261419041","type":"journal-article","created":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T03:44:35Z","timestamp":1771731875000},"page":"471-476","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Clinical Outcomes of Iron Sucrose and Ferric Carboxymaltose in the Treatment of Iron Deficiency Anemia"],"prefix":"10.1177","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3109-0590","authenticated-orcid":false,"given":"Wasim S.","family":"El Nekidy","sequence":"first","affiliation":[{"name":"Cleveland Clinic Abu Dhabi, United Arab Emirates"},{"name":"Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Aldhanhani","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Abu Dhabi, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavinia","family":"Salama","sequence":"additional","affiliation":[{"name":"Long Island University, Brooklyn, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emna","family":"Abidi","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Abu Dhabi, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Shatnawei","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Abu Dhabi, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziad","family":"Sadik","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Abu Dhabi, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Ghosn","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Abu Dhabi, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaher","family":"Koutoubi","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Abu Dhabi, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi","family":"Hijazi","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Abu Dhabi, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihad","family":"Mallat","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Abu Dhabi, United Arab Emirates"},{"name":"Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,21]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/10815589221140597"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-46739-z"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.1998.v32.pm9820470"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084943"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-020-01524-6"},{"key":"e_1_3_2_7_2","unstructured":"World Health Organization. Anaemia in Women and Children. Global Health Observatory (GHO) Data. Accessed January 12 2025. https:\/\/www.who.int\/data\/gho\/data\/themes\/topics\/anaemia_in_women_and_children"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2022.2109557"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2023.08.004"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2019020213"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.05.027"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.163"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu201"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0255104"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-017-0506-8"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-019-2200-3"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.2515"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.2412"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.4212\/cjhp.v68i4.1470"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.5414\/CN110212"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.5414\/CN110066"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40801-024-00418-1"}],"container-title":["Hospital Pharmacy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00185787261419041","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00185787261419041","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00185787261419041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:19:26Z","timestamp":1789715966000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00185787261419041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,21]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1177\/00185787261419041"],"URL":"https:\/\/doi.org\/10.1177\/00185787261419041","relation":{},"ISSN":["0018-5787","1945-1253"],"issn-type":[{"value":"0018-5787","type":"print"},{"value":"1945-1253","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,21]]}}}