{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T01:11:23Z","timestamp":1774573883145,"version":"3.50.1"},"reference-count":26,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2013,10,23]],"date-time":"2013-10-23T00:00:00Z","timestamp":1382486400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hum Factors"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> We aimed to determine if serum biochemical and MRI biomarkers differed between high volume (\u2265 230 texts sent\/day; n = 5) and low volume (\u2264 25 texts sent\/day; n = 5) texters. A secondary aim was to ascertain what correlations between the biochemical and imaging biomarkers could tell us about the pathophysiology of early onset tendinopathies. <\/jats:p><\/jats:sec><jats:sec><jats:title>Background:<\/jats:title><jats:p> Text messaging has become widespread, particularly among college-aged young adults. There is concern that high rates of texting may result in musculoskeletal disorders, including tendinopathies. Pathophysiology of tendinopathies is largely unknown. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> Ten females with a mean age of 20 were recruited. We examined serum for 20 biomarkers of inflammation, tissue degeneration, and repair. We used conventional MRI and MRI mean intratendinous signal intensity (MISI) to assess thumb tendons. Correlations between MISI and serum biomarkers were also examined. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Three high volume texters had MRI tendinopathy findings as did one low volume texter. Increased serum TNF-R1 was found in high volume texters compared to low volume texters, as were nonsignificant increases in MISI in two thumb tendons. Serum TNF-R1 and TNF-\u03b1 correlated with MISI in these tendons, as did IL1-R1. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> These results suggest that early onset tendinopathy with concurrent inflammation may be occurring in prolific texters. Further studies with larger sample sizes are needed for confirmation. <\/jats:p><\/jats:sec><jats:sec><jats:title>Application:<\/jats:title><jats:p> High volume texting may be a risk factor for thumb tendinopathy in later years. Multidisciplinary research using biochemical and imaging biomarkers may be used to gain insight into pathophysiological processes in musculoskeletal disorders. <\/jats:p><\/jats:sec>","DOI":"10.1177\/0018720813507953","type":"journal-article","created":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T02:03:32Z","timestamp":1382580212000},"page":"864-872","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Serum and MRI Biomarkers in Mobile Device Texting"],"prefix":"10.1177","volume":"56","author":[{"given":"Judith E.","family":"Gold","sequence":"first","affiliation":[{"name":"University of G\u00e4vle, G\u00e4vle, Sweden, and Temple University, Philadelphia, Pennsylvania, USA"}]},{"given":"Feroze B.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Temple University Medical School, Philadelphia, Pennsylvania, USA"}]},{"given":"Sayed","family":"Ali","sequence":"additional","affiliation":[{"name":"Temple University Medical School, Philadelphia, Pennsylvania, USA"}]},{"given":"Mary F.","family":"Barbe","sequence":"additional","affiliation":[{"name":"Temple University Medical School, Philadelphia, Pennsylvania, USA"}]}],"member":"179","published-online":{"date-parts":[[2013,10,23]]},"reference":[{"key":"bibr1-0018720813507953","doi-asserted-by":"publisher","DOI":"10.1016\/1043-4666(94)90048-5"},{"key":"bibr2-0018720813507953","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.v16.i1.10"},{"key":"bibr3-0018720813507953","doi-asserted-by":"publisher","DOI":"10.1016\/j.apergo.2010.08.010"},{"key":"bibr4-0018720813507953","volume-title":"Radiology of the foot and ankle","author":"Berquist T. 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