{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:13:19Z","timestamp":1788199999857,"version":"build-2803163510"},"reference-count":55,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Soc Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Exposure to parental problematic alcohol use (PPAU) during childhood represents a common form of early adversity with potential long-term consequences for mental health. While childhood adversity is well established as a risk factor for later psychological difficulties, the specific association between childhood exposure to PPAU and anxiety and depression in adulthood remains insufficiently understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to systematically review and quantitatively synthesize existing evidence on the association between childhood exposure to PPAU and anxiety and depression outcomes in adulthood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A systematic search was conducted in Medline, PsycINFO, Web of Science, and the Cochrane Library. Studies were screened using predefined inclusion criteria. Thirty-two studies met eligibility criteria, of which twenty-nine were included in the meta-analyses. Random-effects models were used to calculate pooled standardized mean differences (SMDs) and odds ratios (ORs) for anxiety and depression outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The findings indicated a significant association between childhood exposure to PPAU and increased risk of anxiety and depression in adulthood. For anxiety, the pooled SMD was 0.37, and pooled ORs indicated a 73% higher likelihood of anxiety among individuals exposed to PPAU. For depression, the pooled SMD was 0.29, with pooled ORs suggesting a 65% increased likelihood of depressive symptoms. Although effect sizes were attenuated in studies adjusting for confounding variables, associations remained statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Childhood exposure to PPAU is associated with an increased risk of anxiety and depression in adulthood. However, the available evidence suggests that these associations may be partly explained by co-occurring childhood adversities and broader family dysfunction. Consequently, PPAU may represent one component of a broader constellation of childhood risk factors associated with adverse adult mental health outcomes. Taken together, these findings underscore the importance of early identification and family-focused preventive interventions for children exposed to parental alcohol problems.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00207640261478546","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:40:20Z","timestamp":1787964020000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Parental Problematic Alcohol Use (PPAU): A Burden for Life?\u2014Exposure to PPAU and Anxiety and Depression in Adulthood: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3830-9297","authenticated-orcid":false,"given":"Ana Sofia","family":"Micael","sequence":"first","affiliation":[{"name":"Faculdade de Medicina da Universidade de Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9379-1734","authenticated-orcid":false,"given":"Filipa","family":"Novais","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina da Universidade de Lisboa, Portugal"},{"name":"Unidade Local de Sa\u00fade Santa Maria, Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19138086"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.53.8.1001"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10826084.2022.2161825"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4603(95)00022-5"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s127-002-8208-8"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dar.13910"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01537148"},{"key":"e_1_3_2_9_1","doi-asserted-by":"crossref","unstructured":"Chassin L. 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