{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:25:15Z","timestamp":1777811115270,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2000,3,1]],"date-time":"2000-03-01T00:00:00Z","timestamp":951868800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:p>The chelating agent 2,3 dimercaptopropane-1-sulfonate (DMPS) has been used in a mercury mobilization test for diagnoses in illnesses allegedly associated with the presence of amalgam restorations. DMPS is an accepted antidote to heavy metal poisoning. The aim of the present study was to evaluate the diagnostic value of DMPS in patients with symptoms self-related to their amalgam fillings. The subjects consisted of four groups: 19 healthy controls without amalgam experience; 21 healthy controls with amalgam fillings; 20 patients who claimed symptoms of \"mercury poisoning\" from dental amalgam; and 20 patients who had amalgam fillings removed because of such symptoms. DMPS (2 mg\/kg body weight) was injected intravenously, and urine was collected prior to the injection, 30 and 120 min after the injection, and throughout the next 22 hrs. The samples were analyzed for total mercury by cold vapor atomic absorption spectrophotometry. The total median amounts of mercury excreted over 24 hrs for those with complaints allegedly associated with amalgam and for the healthy controls with amalgam fillings were similar. Persons with amalgam fillings excreted about three times more mercury than those without. The controls, who had never had amalgam fillings, and the subjects who had had their fillings removed excreted median amounts of 8.5 \u03bcg and 7.2 \u03bcg mercury, respectively. The present DMPS challenge test did not differentiate between patients with or those without complaints self-related to their amalgam fillings but did confirm the higher mercury values in patients with dental amalgam.<\/jats:p>","DOI":"10.1177\/00220345000790031401","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"868-874","source":"Crossref","is-referenced-by-count":24,"title":["Diagnostic Value of a Chelating Agent in Patients with Symptoms Allegedly Caused by Amalgam Fillings"],"prefix":"10.1177","volume":"79","author":[{"given":"J.S.","family":"Vamnes","sequence":"first","affiliation":[{"name":"University of Bergen, Department of Odontology-Dental Biomaterials, Aarstadveien 17, N-5009 Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Eide","sequence":"additional","affiliation":[{"name":"University of Bergen, Department of Odontology-Dental Biomaterials, Aarstadveien 17, N-5009 Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Isrenn","sequence":"additional","affiliation":[{"name":"Dept. of Biochemistry and Molecular Biology, Aarstadveien 19, N-5009 Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.J.","family":"H\u00f6l","sequence":"additional","affiliation":[{"name":"University of Bergen, Department of Odontology-Dental Biomaterials, Aarstadveien 17, N-5009 Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.R.","family":"Gjerdet","sequence":"additional","affiliation":[{"name":"University of Bergen, Department of Odontology-Dental Biomaterials, Aarstadveien 17, N-5009 Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2000,3,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1039\/AN9952000853"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1995.tb00234.x"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(95)02965-B"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(96)03308-2"},{"key":"atypb5","first-page":"354","volume":"28","author":"Barber TE","year":"1986","journal-title":"J Occup Med"},{"key":"atypb6","volume-title":"Dental amalgam: a scientific review and recommended public health service strategy for research, education and regulation. Final report of the Subcommittee on Risk Management of the Committee to Coordinate Environmental Health and Related Programs","author":"Benson JS","year":"1993"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1177\/00220345900690100401"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.1996.tb00046.x"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1177\/00220345880670091701"},{"key":"atypb10","unstructured":"Berlin M. (1986). Mercury. In: Handbook on the toxicology of metals. 2nd ed. Friberg L, Nordberg GF, Voulk V, editors. Amsterdam: Elsevier Science Publishers, pp. 387-445."},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.1997.tb00207.x"},{"key":"atypb12","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0022-3565(25)22659-3","volume":"245","author":"Cherian MG","year":"1988","journal-title":"J Pharmacol Exp Ther"},{"key":"atypb13","first-page":"89","volume":"28","author":"Daunderer M.","year":"1989","journal-title":"Forum Prakt Allgemeinartz"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1006\/enrs.1993.1065"},{"key":"atypb15","first-page":"343","volume":"17","author":"Ewan KB","year":"1996","journal-title":"Neurotoxicology"},{"key":"atypb16","first-page":"204","volume":"40","author":"Fawer RF","year":"1983","journal-title":"Br J Ind Med"},{"key":"atypb17","first-page":"19","volume":"7","author":"Godfrey M.","year":"1994","journal-title":"J Adv Med"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1007\/BF02041243"},{"key":"atypb19","first-page":"271","volume":"194","author":"Herrmann M.","year":"1993","journal-title":"Zentralbl Hyg Umweltmed"},{"key":"atypb20","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/S0022-3565(25)38988-3","volume":"268","author":"Hurlbut KM","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"atypb21","first-page":"803","volume":"35","author":"Kroncke A.","year":"1980","journal-title":"Dtsch Zahn\u00e4rztl Z"},{"key":"atypb22","first-page":"69","volume":"12","author":"Langworth S.","year":"1988","journal-title":"Swed Dent J"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.1454"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.7.15.8262327"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1177\/10454411970080040401"},{"key":"atypb26","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/0006-2952(89)90261-X","volume":"38","author":"Maiorino RM","year":"1989","journal-title":"Biochem Pharmacol"},{"key":"atypb27","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/S0022-3565(25)20546-8","volume":"259","author":"Maiorino RM","year":"1991","journal-title":"J Pharmacol Exp Ther"},{"key":"atypb28","first-page":"179","volume":"11","author":"Nylander M.","year":"1987","journal-title":"Swed Dent J"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1177\/00220345920710021201"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1177\/00220345870660061701"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1996.9936021"},{"key":"atypb32","first-page":"130","volume":"22","author":"Oster 0","year":"1985","journal-title":"Intensivmedizin"},{"key":"atypb33","first-page":"603","volume":"22","author":"Petrunkin VE","year":"1956","journal-title":"Ukr Khim Zh"},{"key":"atypb34","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.4700070106"},{"key":"atypb35","volume-title":"DMPS mobilization test. In: DMPS-Heyl. Summary of scientific literature","author":"Ruprecht J.","year":"1993"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1177\/00220345960750011301"},{"key":"atypb37","doi-asserted-by":"publisher","DOI":"10.1177\/00220345980770041501"},{"key":"atypb38","first-page":"1866","volume":"79","author":"Schiele R.","year":"1989","journal-title":"Zahn\u00e4rztl Mitt"},{"key":"atypb39","first-page":"249","volume":"24","author":"Schiele R.","year":"1989","journal-title":"Arbeitsmed Sozialmed Praventivmed"},{"key":"atypb40","doi-asserted-by":"publisher","DOI":"10.1016\/0048-9697(94)90327-1"},{"key":"atypb41","unstructured":"Socialstyrelsen (1994). Blir man sjuk av amalgam? SoS-rapport. Socialstyrelsen. Stockholm. Sweden 1994:21. ISBN 91-38-11407-0. ISSN 100-2808."},{"key":"atypb42","first-page":"59","volume":"23","author":"Stenman S.","year":"1997","journal-title":"Scand J Work Environ Health"},{"key":"atypb43","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.4.825"},{"key":"atypb44","doi-asserted-by":"publisher","DOI":"10.1177\/00220345850640080901"},{"key":"atypb45","volume-title":"Pharmakokinetik der uroprotektiven Sulfhydrylgruppen in Urin gesunder Probanden nach peroraler Verabreichung von Na-mercaptoethansulfonat (Uromexitan) und von Na-Dimercaptopropansulfonat (Dimaval) (dissertation)","author":"Waelti S.","year":"1992"},{"key":"atypb46","doi-asserted-by":"publisher","DOI":"10.1016\/0048-9697(93)90408-X"},{"key":"atypb47","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2797(82)90130-2"}],"container-title":["Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00220345000790031401","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00220345000790031401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:01:51Z","timestamp":1777496511000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00220345000790031401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,3]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,3]]}},"alternative-id":["10.1177\/00220345000790031401"],"URL":"https:\/\/doi.org\/10.1177\/00220345000790031401","relation":{},"ISSN":["0022-0345","1544-0591"],"issn-type":[{"value":"0022-0345","type":"print"},{"value":"1544-0591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,3]]}}}