{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:25:25Z","timestamp":1777811125577,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2000,4,1]],"date-time":"2000-04-01T00:00:00Z","timestamp":954547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2000,4]]},"abstract":"<jats:p>The GRP-Ca gene of the rat encodes a member of the glutamine\/glutamic-acid-rich protein (GRP) family. This gene is expressed in a highly tissue-specific fashion, with transcription being found only in the acinar cells of the submandibular gland (SMG). To begin to define the cis-acting elements governing GRP-Ca expression, we constructed transgenic mice containing the rat GRP-Ca gene plus 9.5 kb of 5' genomic sequence and 1 kb of 3' genomic sequence. Expression of GRP-Ca was detectable in progeny from only 1 of 3 independent founders. Expression levels of the transgenic GRP-Ca were much lower than the native GRP-Ca found in the rat SMG. Furthermore, GRP-Ca in transgenic mice was not tissue-specifically expressed, being found in both the SMG\/SLG complex and the liver. These results indicate that the genomic region of GRP-Ca included in these transgenic mice is not sufficient to confer the high levels of tissue-specific expression seen in the rat.<\/jats:p>","DOI":"10.1177\/00220345000790040701","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"926-929","source":"Crossref","is-referenced-by-count":0,"title":["Low Levels of GRP-Ca Expression in Transgenic Mice"],"prefix":"10.1177","volume":"79","author":[{"given":"K.G.","family":"Ten Hagen","sequence":"first","affiliation":[{"name":"Center for Oral Biology, Aab Institute of Biomedical Sciences, University of Rochester Medical Center, 601 Elmwood Avenue, Box 611, Rochester, NY 14642"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.M.","family":"Balys","sequence":"additional","affiliation":[{"name":"Center for Oral Biology, Aab Institute of Biomedical Sciences, University of Rochester Medical Center, 601 Elmwood Avenue, Box 611, Rochester, NY 14642"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2000,4,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb09638.x"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.10.4189"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6603(08)60005-7"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(91)90208-S"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)67828-2"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)42380-5"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.21.13843"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)61183-4"},{"key":"atypb9","unstructured":"Hogan B., Costantini F., Lacy E. 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