{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:12:19Z","timestamp":1789711939920,"version":"4.0.1"},"reference-count":27,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2001,6,1]],"date-time":"2001-06-01T00:00:00Z","timestamp":991353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2001,6]]},"abstract":"<jats:p>Tumor necrosis factor-a. (TNF-a), a pro-inflammatory cytokine, can stimulate matrix metalloproteinase synthesis and osteoclastic bone resorption. We hypothesized that elevated expression of TNF-a and its p55 and p75 receptors (TNF-R) in gingival tissue might associate with periodontitis. Immunohistochemistry was used for the study of the localization of TNF-a and its p55 and p75 TNF-R in adult periodontitis (AP) gingival tissue, in comparison with that in healthy control specimens. TNF-a and p55 TNF-R were detected in sulcular epithelial basal cells and in monocyte\/macrophages, fibroblasts, and endothelial cells in the AP gingival tissue specimens, but mainly in fibroblasts and endothelial cells in control specimens. P75 TNF-R was occasionally found in monocyte\/macrophage-like cells in gingival tissue specimens. The percentage of TNF-a-containing cells was not increased in AP compared with controls (13.2% \u00b1 6.1% vs. 12.8% \u00b1 7.6%), but, due to the increased cellularity of AP samples, the number of TNF-a positive cells\/mm2 was clearly increased (1621 \u00b1 663 vs. 664 \u00b1191, p &gt; 0.001). Thus, AP gingival tissue has an elevated expression of TNF-a and especially its p55 receptor, suggesting that TNF-a may contribute to tissue degradation in periodontitis.<\/jats:p>","DOI":"10.1177\/00220345010800061101","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"1535-1539","source":"Crossref","is-referenced-by-count":54,"title":["Tumor Necrosis Factor-a and its Receptors, p55 and p75, in Gingiva of Adult Periodontitis"],"prefix":"10.1177","volume":"80","author":[{"given":"T.","family":"Tervahartiala","sequence":"first","affiliation":[{"name":"Departments of Medicine\/invartes medicin, University of Helsinki, Finland,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Koski","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Biomedicum Helsinki, University of Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-W.","family":"Xu","sequence":"additional","affiliation":[{"name":"Departments of Medicine\/invartes medicin, University of Helsinki, Finland, Division of Rheumatic Diseases, Long Island Jewish Medical Center, New Hyde Park, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"H\u00e4yrinen-Immonen","sequence":"additional","affiliation":[{"name":"Departments of Medicine\/invartes medicin, University of Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hietanen","sequence":"additional","affiliation":[{"name":"Deparmtent of Oral Pathology Unit\/Laboratory Diagnostics, Helsinki University Central Hospital, University of Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Sorsa","sequence":"additional","affiliation":[{"name":"Departments of Medicine\/invartes medicin, University of Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.T.","family":"Konttinen","sequence":"additional","affiliation":[{"name":"Departments of Medicine\/invartes medicin, University of Helsinki, Finland, Department of Anatomy, Biomedicum Helsinki, University of Helsinki, Finland, ORTON Research Institute, Invalid Foundation, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2001,6,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119679"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1993.tb02113.x"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1177\/00220345960750121101"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1528.1528"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00194.x"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1042\/bj2960803"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.50.31504"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.1995.tb00192.x"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1177\/29.4.6166661"},{"key":"atypb10","first-page":"243","volume":"8","author":"Johansson N.","year":"1997","journal-title":"Cell Growth Differ"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.3.1544"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/S0268-0890(97)90050-5"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1995.tb01788.x"},{"key":"atypb14","unstructured":"Lindhe J., Nyman S. 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