{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:36:11Z","timestamp":1792002971586,"version":"4.4.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2001,6,1]],"date-time":"2001-06-01T00:00:00Z","timestamp":991353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2001,6]]},"abstract":"<jats:p>\n                    Previous studies suggest that salivary and pulp-derived host enzymes, matrix metalloproteinases (MMPs), may be involved in dentin caries pathogenesis. To study the inhibition of acid-activated human salivary MMPs by non-antimicrobial chemically modified tetracyclines (CMTs), we used a functional activity assay with\n                    <jats:sup>125<\/jats:sup>\n                    I-labeled gelatin as a substrate. To address the role of MMPs in the progression of fissure caries in vivo, we administered the MMP inhibitors CMT-3 and zoledronate to young rats per os for 7 weeks, 5 days a week. Caries lesions were visualized by Schiff reagent in sagittally sectioned mandibular molars. Marked reduction in gelatinolytic activity of human salivary MMPs was observed with CMT-3. CMT-3 and zoledronate, both alone and in combination, also reduced dentin caries progression in the rats. These results suggest that MMPs have an important role in dentin caries pathogenesis, and that MMP inhibitors may prove to be useful in the prevention of caries progression.\n                  <\/jats:p>","DOI":"10.1177\/00220345010800061301","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T19:39:42Z","timestamp":1231443582000},"page":"1545-1549","source":"Crossref","is-referenced-by-count":136,"title":["The Effects of MMP Inhibitors on Human Salivary MMP Activity and Caries Progression in Rats"],"prefix":"10.1177","volume":"80","author":[{"given":"M.","family":"Sulkala","sequence":"first","affiliation":[{"name":"Institute of Dentistry, University of Oulu, PO Box 5281, FIN-90014 University of Oulu, Finland,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Wahlgren","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biomedicum, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Larmas","sequence":"additional","affiliation":[{"name":"'Institute of Dentistry, University of Oulu, PO Box 5281, FIN-90014 University of Oulu, Finland, Oulu University Hospital, Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Sorsa","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biomedicum, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Teronen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biomedicum, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Salo","sequence":"additional","affiliation":[{"name":"'Institute of Dentistry, University of Oulu, PO Box 5281, FIN-90014 University of Oulu, Finland, Oulu University Hospital, Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Tj\u00e4derhane","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2001,6,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/0955-0674(95)80116-2"},{"key":"atypb2","first-page":"2949","volume":"60","author":"Boissier S.","year":"2000","journal-title":"Cancer Res"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1177\/08959374980120011501"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1986.tb00651.x"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(83)90126-7"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1159\/000262119"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-6009(08)80055-4"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1177\/00220345870660080401"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1177\/10454411910020030201"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1177\/08959374980120010501"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1177\/00220345930720121001"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.3109\/00016359609003539"},{"key":"atypb13","first-page":"40","volume":"42","author":"Katz S.","year":"1987","journal-title":"J Oral Med"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1177\/00220345970760011001"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91484-6"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1021\/bi972120y"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(00)00052-2"},{"key":"atypb18","unstructured":"National Research Council (1972). Nutrient requirements of the laboratory rats. In: Committee on animal nutrition (editors). Nutrient requirements of laboratory animals . No. 10. 2nd ed. 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