{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:32:01Z","timestamp":1777811521566,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p>Cytokines released by immune system cells play an important role in cyst enlargement. This study aimed to determine, by ELISA, the levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin 3 (IL-3), and IL-6 in fluid and tissue from human radicular cysts. GM-CSF was found in 42.8% of the fluid samples (164.3 pg\/mL) and IL-6 in 92.8% (641.4 pg\/mL). No IL-3 was detected in any fluid samples. In the tissue samples, 28.6% were positive for IL-3 (369.2 pg\/mL), 86.4% for IL-6 (92.4 pg\/mL), and 95.8% for GM-CSF (200.5 pg\/mL). It can be concluded that GM-CSF and IL-6 were widely found in the fluid and tissue samples. In contrast, IL-3 was found only in the cystic tissue, even though in few lesions. These cytokines may contribute to the inflammation, cystic growth, and bone resorption that characterize cystic lesions.<\/jats:p>","DOI":"10.1177\/002203450208100114","type":"journal-article","created":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T04:44:51Z","timestamp":1506660291000},"page":"64-68","source":"Crossref","is-referenced-by-count":7,"title":["Levels of GM-CSF, IL-3, and IL-6 in Fluid and Tissue from Human Radicular Cysts"],"prefix":"10.1177","volume":"81","author":[{"given":"A.M.","family":"Gerv\u00e1sio","sequence":"first","affiliation":[{"name":"Division of Immunology, Institute of Biomedical Sciences, Federal University of Uberl\u00e2ndia, Uberl\u00e2ndia (MG), Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.A.O.","family":"Silva","sequence":"additional","affiliation":[{"name":"Division of Immunology, Institute of Biomedical Sciences, Federal University of Uberl\u00e2ndia, Uberl\u00e2ndia (MG), Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.A.","family":"Taketomi","sequence":"additional","affiliation":[{"name":"Division of Immunology, Institute of Biomedical Sciences, Federal University of Uberl\u00e2ndia, Uberl\u00e2ndia (MG), Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.J.A.","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Clinic and Operative Dentistry and Endodontics, School of Dentistry, Federal University of Uberl\u00e2ndia, Uberl\u00e2ndia (MG), Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S-S.J.","family":"Sung","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Health Sciences Center, University of Virginia, Charlottesville, VA, USA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.M.","family":"Loyola","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, School of Dentistry, Federal University of Uberl\u00e2ndia, Av. 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