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Mouth air of 40 healthy volunteers and 40 persons with halitosis was analyzed and compared by gas chromatography-mass spectrometry, two sulfur monitors, and organoleptically. Nearly 700 different compounds were detected. Hydrogen sulfide, methyl mercaptan, dimethyl sulfide, di- and trisulfide were increased in persons with breath odor. These compounds were all significantly correlated with the organoleptic score. We concluded that hydrogen sulfide, methyl mercaptan and, to a much lesser extent, dimethyl sulfide, di- and trisulfide can contribute to oral malodor. The role of other compounds, such as amines and organic acids, seems insignificant.<\/jats:p>","DOI":"10.1177\/0022034508329741","type":"journal-article","created":{"date-parts":[[2009,3,27]],"date-time":"2009-03-27T00:58:28Z","timestamp":1238115508000},"page":"285-289","source":"Crossref","is-referenced-by-count":107,"title":["Detection of Odorous Compounds in Breath"],"prefix":"10.1177","volume":"88","author":[{"given":"S.","family":"Van den Velde","sequence":"first","affiliation":[{"name":"Department of Periodontology, Catholic University of Leuven, Kapucijnenvoer 33, BE-3000 Leuven, Belgium; and"},{"name":"Laboratory for Biochemistry and Toxicology, Ziekenhuis Netwerk Antwerpen Stuivenberg, Lange Beeldekensstraat 267, 2060 Antwerpen, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"van Steenberghe","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Catholic University of Leuven, Kapucijnenvoer 33, BE-3000 Leuven, Belgium; and"},{"name":"Laboratory for Biochemistry and Toxicology, Ziekenhuis Netwerk Antwerpen Stuivenberg, Lange Beeldekensstraat 267, 2060 Antwerpen, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Van hee","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Catholic University of Leuven, Kapucijnenvoer 33, BE-3000 Leuven, Belgium; and"},{"name":"Laboratory for Biochemistry and Toxicology, Ziekenhuis Netwerk Antwerpen Stuivenberg, Lange Beeldekensstraat 267, 2060 Antwerpen, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Quirynen","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Catholic University of Leuven, Kapucijnenvoer 33, BE-3000 Leuven, Belgium; and"},{"name":"Laboratory for Biochemistry and Toxicology, Ziekenhuis Netwerk Antwerpen Stuivenberg, Lange Beeldekensstraat 267, 2060 Antwerpen, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,3,26]]},"reference":[{"key":"AWANO-ETAL-2004","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2004.06.001"},{"key":"BENJAMINI-AND-HOCHBERG-1995","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"BLOM-AND-TANGERMAN-1988","unstructured":"Blom HJ, Tangerman A (1988). 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