{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T02:21:49Z","timestamp":1783736509351,"version":"3.55.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:p>We previously demonstrated a role for \u03b111\u03b21 integrin in periodontal ligament (PDL)-driven tooth eruption in the mouse. To explore a possible role for \u03b111\u03b21 in the human periodontium, we have characterized the expression and function of \u03b111 in human PDL tissue, in human PDL fibroblasts (hPDLF), and in human gingival fibroblasts (hGF). \u03b111 expression was detected in PDL tissue, in hPDLF, and in hGF cells. Platelet-derived growth factor-BB and insulin-like growth factor II stimulated contraction of collagen lattices by both types of fibroblasts. \u03b12 integrin blocking antibodies and the use of \u03b111 siRNA demonstrated a role for both \u03b12\u03b21 and \u03b111\u03b21 in collagen lattice remodeling. Analysis of the proximal ITGA11 promoter from persons with chronic periodontal disease failed to reveal any polymorphism. Analysis of our data shows that \u03b111\u03b21 is a major collagen receptor on cultured human PDL cells and implies that it is also functionally important in the PDL in vivo.<\/jats:p>","DOI":"10.1177\/0022034509339291","type":"journal-article","created":{"date-parts":[[2009,7,29]],"date-time":"2009-07-29T15:17:55Z","timestamp":1248880675000},"page":"621-626","source":"Crossref","is-referenced-by-count":38,"title":["A Role for \u03b111\u03b21 Integrin in the Human Periodontal Ligament"],"prefix":"10.1177","volume":"88","author":[{"given":"M.M.","family":"Barczyk","sequence":"first","affiliation":[{"name":"Department of Clinical Dentistry - Periodontics, University of Bergen, Aarstadveien 17, N-5009 Bergen, Norway;"},{"name":"Department of Biomedicine - Physiology, University of Bergen, Norway;"},{"name":"Department of Periodontology, Academic Center for Dentistry Amsterdam -ACTA-, University of Amsterdam and Vrije University, The Netherlands; and"},{"name":"Department of Clinical Dentistry\u2014Center for Clinical Dental Research, University of Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.-H. Borge","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Dentistry - Periodontics, University of Bergen, Aarstadveien 17, N-5009 Bergen, Norway;"},{"name":"Department of Biomedicine - Physiology, University of Bergen, Norway;"},{"name":"Department of Periodontology, Academic Center for Dentistry Amsterdam -ACTA-, University of Amsterdam and Vrije University, The Netherlands; and"},{"name":"Department of Clinical Dentistry\u2014Center for Clinical Dental Research, University of Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"da Franca","sequence":"additional","affiliation":[{"name":"Department of Clinical Dentistry - Periodontics, University of Bergen, Aarstadveien 17, N-5009 Bergen, Norway;"},{"name":"Department of Biomedicine - Physiology, University of Bergen, Norway;"},{"name":"Department of Periodontology, Academic Center for Dentistry Amsterdam -ACTA-, University of Amsterdam and Vrije University, The Netherlands; 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