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Natural tooth substitution based on copying the developmental process of tooth formation is particularly challenging and creates a rapidly developing area of molecular dentistry. In any approach, functional interactions among the tooth, the surrounding bone, and the periodontium must be established. Therefore, recent research in craniofacial genetics searches for mechanisms responsible for correct cell and tissue interactions, not only within a specific structure, but also in the context of supporting structures. A tooth crown that is not functionally anchored to roots and bone is useless. This review aims to summarize the developmental and tissue homeostatic aspects of the tooth-bone interface, from the initial patterning toward tooth eruption and lifelong interactions between the tooth and its surrounding alveolar bone.<\/jats:p>","DOI":"10.1177\/0022034509355440","type":"journal-article","created":{"date-parts":[[2009,12,30]],"date-time":"2009-12-30T22:23:17Z","timestamp":1262211797000},"page":"108-115","source":"Crossref","is-referenced-by-count":67,"title":["Formation of the Tooth-Bone Interface"],"prefix":"10.1177","volume":"89","author":[{"given":"J.","family":"Fleischmannova","sequence":"first","affiliation":[{"name":"Laboratory of Animal Embryology, Institute of Animal Physiology and Genetics CAS v.v.i., Veveri 97, 602 00 Brno, Czech Republic;"},{"name":"Department of Animal Physiology, Faculty of Sciences, University of South Bohemia, Ceske Budejovice, Czech Republic;"},{"name":"Department of Physiology and Pathophysiology, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic;"},{"name":"Department of Craniofacial Development, Dental Institute, Kings College London, Guys Hospital, London Bridge, London, UK;"},{"name":"Biomedical Research Centre, London, UK; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Matalova","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Embryology, Institute of Animal Physiology and Genetics CAS v.v.i., Veveri 97, 602 00 Brno, Czech Republic;"},{"name":"Department of Animal Physiology, Faculty of Sciences, University of South Bohemia, Ceske Budejovice, Czech Republic;"},{"name":"Department of Physiology and Pathophysiology, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic;"},{"name":"Department of Craniofacial Development, Dental Institute, Kings College London, Guys Hospital, London Bridge, London, UK;"},{"name":"Biomedical Research Centre, London, UK; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.T.","family":"Sharpe","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Embryology, Institute of Animal Physiology and Genetics CAS v.v.i., Veveri 97, 602 00 Brno, Czech Republic;"},{"name":"Department of Animal Physiology, Faculty of Sciences, University of South Bohemia, Ceske Budejovice, Czech Republic;"},{"name":"Department of Physiology and Pathophysiology, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic;"},{"name":"Department of Craniofacial Development, Dental Institute, Kings College London, Guys Hospital, London Bridge, London, UK;"},{"name":"Biomedical Research Centre, London, UK; 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