{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:03:57Z","timestamp":1785330237015,"version":"3.55.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2010,2,22]],"date-time":"2010-02-22T00:00:00Z","timestamp":1266796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:p>\n                    COX-2 plays an important role in periodontitis by mediating inflammatory reactions in periodontal tissues, and the COX-2 polymorphisms rs20417 and rs689466 have been reported to be associated with periodontitis in populations of Taiwanese and Chinese ethnicity. To test whether these variants were associated with periodontitis in populations of European ethnicity, we genotyped the single-nucleotide polymorphisms (SNPs) rs689466 and rs6681231, the latter a haplotype tagging SNP (htSNP) for rs20417 (r\n                    <jats:sup>2<\/jats:sup>\n                    &gt;0.95), in our large-analysis population of individuals with aggressive (n = 532) and chronic periodontitis (n = 1052), and 2873 healthy control individuals. The rare G allele of htSNP rs6681231 was associated with aggressive periodontitis prior to and after adjustment for the covariates smoking, diabetes, and gender, with an odds ratio of 1.57 (95% confidence interval 1.18\u20132.08; p = 0.002). The validation of the association of rs20417 by the htSNP rs6681231 provides evidence for a general genetic risk of COX-2 variants in the pathogenesis of periodontitis.\n                  <\/jats:p>","DOI":"10.1177\/0022034509359575","type":"journal-article","created":{"date-parts":[[2010,2,22]],"date-time":"2010-02-22T23:05:49Z","timestamp":1266879949000},"page":"384-388","source":"Crossref","is-referenced-by-count":47,"title":["<i>COX-2<\/i>\n                    Is Associated with Periodontitis in Europeans"],"prefix":"10.1177","volume":"89","author":[{"given":"A.S.","family":"Schaefer","sequence":"first","affiliation":[{"name":"Christian-Albrechts-University, Institute for Clinical Molecular Biology, Schittenhelmstra\u00dfe 12, 24105 Kiel, Germany;"},{"name":"Christian-Albrechts-University, Institute of Medical Informatics and Statistics, House 31, Arnold-Heller-Stra\u00dfe 3, 24105 Kiel, Germany;"},{"name":"Department of Oral Microbiology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, van der Boechorststraat 7, 1081 BT Amsterdam, the Netherlands;"},{"name":"University Medical Center Carl Gustav Carus der Technischen Universit\u00e4t Dresden, Zentrum f\u00fcr Zahn-, Mund- und Kieferheilkunde, Poliklinik f\u00fcr Zahnerhaltung, Fetscherstra\u00dfe 74, 01307 Dresden, Germany;"},{"name":"Department of Preventive Dentistry and Periodontology, University of Munich, Goethestra\u00dfe 70, 80336 Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.M.","family":"Richter","sequence":"additional","affiliation":[{"name":"Christian-Albrechts-University, Institute for Clinical Molecular Biology, Schittenhelmstra\u00dfe 12, 24105 Kiel, Germany;"},{"name":"Christian-Albrechts-University, Institute of Medical Informatics and Statistics, House 31, Arnold-Heller-Stra\u00dfe 3, 24105 Kiel, Germany;"},{"name":"Department of Oral Microbiology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, van der Boechorststraat 7, 1081 BT Amsterdam, the Netherlands;"},{"name":"University Medical Center Carl Gustav Carus der Technischen Universit\u00e4t Dresden, Zentrum f\u00fcr Zahn-, Mund- und Kieferheilkunde, Poliklinik f\u00fcr Zahnerhaltung, Fetscherstra\u00dfe 74, 01307 Dresden, Germany;"},{"name":"Department of Preventive Dentistry and Periodontology, University of Munich, Goethestra\u00dfe 70, 80336 Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Nothnagel","sequence":"additional","affiliation":[{"name":"Christian-Albrechts-University, Institute for Clinical Molecular Biology, Schittenhelmstra\u00dfe 12, 24105 Kiel, Germany;"},{"name":"Christian-Albrechts-University, Institute of Medical Informatics and Statistics, House 31, Arnold-Heller-Stra\u00dfe 3, 24105 Kiel, Germany;"},{"name":"Department of Oral Microbiology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, van der Boechorststraat 7, 1081 BT Amsterdam, the Netherlands;"},{"name":"University Medical Center Carl Gustav Carus der Technischen Universit\u00e4t Dresden, Zentrum f\u00fcr Zahn-, Mund- und Kieferheilkunde, Poliklinik f\u00fcr Zahnerhaltung, Fetscherstra\u00dfe 74, 01307 Dresden, Germany;"},{"name":"Department of Preventive Dentistry and Periodontology, University of Munich, Goethestra\u00dfe 70, 80336 Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.L.","family":"Laine","sequence":"additional","affiliation":[{"name":"Christian-Albrechts-University, Institute for Clinical Molecular Biology, Schittenhelmstra\u00dfe 12, 24105 Kiel, Germany;"},{"name":"Christian-Albrechts-University, Institute of Medical Informatics and Statistics, House 31, Arnold-Heller-Stra\u00dfe 3, 24105 Kiel, Germany;"},{"name":"Department of Oral Microbiology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, van der Boechorststraat 7, 1081 BT Amsterdam, the Netherlands;"},{"name":"University Medical Center Carl Gustav Carus der Technischen Universit\u00e4t Dresden, Zentrum f\u00fcr Zahn-, Mund- und Kieferheilkunde, Poliklinik f\u00fcr Zahnerhaltung, Fetscherstra\u00dfe 74, 01307 Dresden, Germany;"},{"name":"Department of Preventive Dentistry and Periodontology, University of Munich, Goethestra\u00dfe 70, 80336 Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Noack","sequence":"additional","affiliation":[{"name":"Christian-Albrechts-University, Institute for Clinical Molecular Biology, Schittenhelmstra\u00dfe 12, 24105 Kiel, Germany;"},{"name":"Christian-Albrechts-University, Institute of Medical Informatics and Statistics, House 31, Arnold-Heller-Stra\u00dfe 3, 24105 Kiel, Germany;"},{"name":"Department of Oral Microbiology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, van der Boechorststraat 7, 1081 BT Amsterdam, the Netherlands;"},{"name":"University Medical Center Carl Gustav Carus der Technischen Universit\u00e4t Dresden, Zentrum f\u00fcr Zahn-, Mund- und Kieferheilkunde, Poliklinik f\u00fcr Zahnerhaltung, Fetscherstra\u00dfe 74, 01307 Dresden, Germany;"},{"name":"Department of Preventive Dentistry and Periodontology, University of Munich, Goethestra\u00dfe 70, 80336 Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Glas","sequence":"additional","affiliation":[{"name":"Christian-Albrechts-University, Institute for Clinical Molecular Biology, Schittenhelmstra\u00dfe 12, 24105 Kiel, Germany;"},{"name":"Christian-Albrechts-University, Institute of Medical Informatics and Statistics, House 31, Arnold-Heller-Stra\u00dfe 3, 24105 Kiel, Germany;"},{"name":"Department of Oral Microbiology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, van der Boechorststraat 7, 1081 BT Amsterdam, the Netherlands;"},{"name":"University Medical Center Carl Gustav Carus der Technischen Universit\u00e4t Dresden, Zentrum f\u00fcr Zahn-, Mund- und Kieferheilkunde, Poliklinik f\u00fcr Zahnerhaltung, Fetscherstra\u00dfe 74, 01307 Dresden, Germany;"},{"name":"Department of Preventive Dentistry and Periodontology, University of Munich, Goethestra\u00dfe 70, 80336 Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Schrezenmeir","sequence":"additional","affiliation":[{"name":"Christian-Albrechts-University, Institute for Clinical Molecular Biology, Schittenhelmstra\u00dfe 12, 24105 Kiel, Germany;"},{"name":"Christian-Albrechts-University, Institute of Medical Informatics and Statistics, House 31, Arnold-Heller-Stra\u00dfe 3, 24105 Kiel, Germany;"},{"name":"Department of Oral Microbiology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, van der Boechorststraat 7, 1081 BT Amsterdam, the Netherlands;"},{"name":"University Medical Center Carl Gustav Carus der Technischen Universit\u00e4t Dresden, Zentrum f\u00fcr Zahn-, Mund- und Kieferheilkunde, Poliklinik f\u00fcr Zahnerhaltung, Fetscherstra\u00dfe 74, 01307 Dresden, Germany;"},{"name":"Department of Preventive Dentistry and Periodontology, University of Munich, Goethestra\u00dfe 70, 80336 Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Groessner-Schreiber","sequence":"additional","affiliation":[{"name":"Christian-Albrechts-University, Institute for Clinical Molecular Biology, Schittenhelmstra\u00dfe 12, 24105 Kiel, Germany;"},{"name":"Christian-Albrechts-University, Institute of Medical Informatics and Statistics, House 31, Arnold-Heller-Stra\u00dfe 3, 24105 Kiel, Germany;"},{"name":"Department of Oral Microbiology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, van der Boechorststraat 7, 1081 BT Amsterdam, the Netherlands;"},{"name":"University Medical Center Carl Gustav Carus der Technischen Universit\u00e4t Dresden, Zentrum f\u00fcr Zahn-, Mund- und Kieferheilkunde, Poliklinik f\u00fcr Zahnerhaltung, Fetscherstra\u00dfe 74, 01307 Dresden, Germany;"},{"name":"Department of Preventive Dentistry and Periodontology, University of Munich, Goethestra\u00dfe 70, 80336 Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Jepsen","sequence":"additional","affiliation":[{"name":"Christian-Albrechts-University, Institute for Clinical Molecular Biology, Schittenhelmstra\u00dfe 12, 24105 Kiel, Germany;"},{"name":"Christian-Albrechts-University, Institute of Medical Informatics and Statistics, House 31, Arnold-Heller-Stra\u00dfe 3, 24105 Kiel, Germany;"},{"name":"Department of Oral Microbiology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, van der Boechorststraat 7, 1081 BT Amsterdam, the Netherlands;"},{"name":"University Medical Center Carl Gustav Carus der Technischen Universit\u00e4t Dresden, Zentrum f\u00fcr Zahn-, Mund- und Kieferheilkunde, Poliklinik f\u00fcr Zahnerhaltung, Fetscherstra\u00dfe 74, 01307 Dresden, Germany;"},{"name":"Department of Preventive Dentistry and Periodontology, University of Munich, Goethestra\u00dfe 70, 80336 Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.G.","family":"Loos","sequence":"additional","affiliation":[{"name":"Christian-Albrechts-University, Institute for Clinical Molecular Biology, Schittenhelmstra\u00dfe 12, 24105 Kiel, Germany;"},{"name":"Christian-Albrechts-University, Institute of Medical Informatics and Statistics, House 31, Arnold-Heller-Stra\u00dfe 3, 24105 Kiel, Germany;"},{"name":"Department of Oral Microbiology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, van der Boechorststraat 7, 1081 BT Amsterdam, the Netherlands;"},{"name":"University Medical Center Carl Gustav Carus der Technischen Universit\u00e4t Dresden, Zentrum f\u00fcr Zahn-, Mund- und Kieferheilkunde, Poliklinik f\u00fcr Zahnerhaltung, Fetscherstra\u00dfe 74, 01307 Dresden, Germany;"},{"name":"Department of Preventive Dentistry and Periodontology, University of Munich, Goethestra\u00dfe 70, 80336 Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Christian-Albrechts-University, Institute for Clinical Molecular Biology, Schittenhelmstra\u00dfe 12, 24105 Kiel, Germany;"},{"name":"Christian-Albrechts-University, Institute of Medical Informatics and Statistics, House 31, Arnold-Heller-Stra\u00dfe 3, 24105 Kiel, Germany;"},{"name":"Department of Oral Microbiology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, van der Boechorststraat 7, 1081 BT Amsterdam, the 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