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Ihh deficiency caused condylar disorganization and growth retardation and reduced polymorphic cell layer proliferation. Expression of Sox9, Runx2, and Osterix was low, as was that of collagen II, collagen I, and aggrecan, thus altering the fibrocartilaginous nature of the condyle. Though a disc formed, it exhibited morphological defects, partial fusion with the glenoid bone surface, reduced synovial cavity space, and, unexpectedly, higher lubricin expression. Analysis of the data shows, for the first time, that continuous Ihh action is required for completion of post-natal TMJ growth and organization. Lubricin overexpression in mutants may represent a compensatory response to sustain TMJ movement and function.<\/jats:p>","DOI":"10.1177\/0022034510363078","type":"journal-article","created":{"date-parts":[[2010,3,3]],"date-time":"2010-03-03T22:55:07Z","timestamp":1267656907000},"page":"349-354","source":"Crossref","is-referenced-by-count":68,"title":["Indian Hedgehog Roles in Post-natal TMJ Development and Organization"],"prefix":"10.1177","volume":"89","author":[{"given":"T.","family":"Ochiai","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Thomas Jefferson University College of Medicine, 1015 Walnut Street, Curtis Building Room 501, Philadelphia, PA 19107, USA;"},{"name":"Department of Oral Pathology, Matsumoto Dental University School of Dentistry, Nagano 399-0781, Japan;"},{"name":"Department of Periodontology, Tokyo Dental College, Chiba, 261-8502, Japan;"},{"name":"Department of Oral Pathology, Asahi University School of Dentistry, Mizuho, Gifu, 501-0296, Japan; 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