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A. actinomycetemcomitans secretes a protein toxin, leukotoxin (LtxA), which helps the bacterium evade the host immune response during infection. LtxA is a membrane-active toxin that specifically targets white blood cells (WBCs). In this review, we discuss recent developments in this field, including the identification and characterization of genes and proteins involved in secretion, regulation of LtxA, biosynthesis, newly described activities of LtxA, and how LtxA may be used as a therapy for the treatment of diseases.<\/jats:p>","DOI":"10.1177\/0022034510363682","type":"journal-article","created":{"date-parts":[[2010,3,3]],"date-time":"2010-03-03T22:55:07Z","timestamp":1267656907000},"page":"561-570","source":"Crossref","is-referenced-by-count":124,"title":["<i>Aggregatibacter actinomycetemcomitans<\/i>\n                    Leukotoxin"],"prefix":"10.1177","volume":"89","author":[{"given":"S.C.","family":"Kachlany","sequence":"first","affiliation":[{"name":"Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, 185 S. 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