{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:42:18Z","timestamp":1777812138326,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2010,4,6]],"date-time":"2010-04-06T00:00:00Z","timestamp":1270512000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:p>Genetics is an important component in the determination of individual susceptibility to caries and periodontal diseases. Since beta defensin 1 (DEFB1) localizes in the oral cavity, we tested if variation in DEFB1 is associated with caries and periodontitis. We analyzed 3 single-nucleotide polymorphisms in DEFB1 in DNA samples from unrelated individuals. Carrying a copy of the variant allele of the DEFB1 marker rs11362 (G-20A) increased the DMFT and DMFS scores more than five-fold. Also, carrying a copy of the variant allele of the DEFB1 marker rs179946 (G-52A) correlated with low DMFT scores. We found a high-caries-experience haplotype (GCA), which increased DMFT scores two-fold, and a low- caries-experience haplotype (ACG), which decreased DMFT scores two-fold, in the DEFB1 promoter. No association between DEFB1 genetic markers and periodontal disease was found. Our results suggest that functional polymorphisms of DEFB1 are potential markers for caries.<\/jats:p>","DOI":"10.1177\/0022034510364491","type":"journal-article","created":{"date-parts":[[2010,4,7]],"date-time":"2010-04-07T01:46:13Z","timestamp":1270604773000},"page":"631-636","source":"Crossref","is-referenced-by-count":79,"title":["The Antimicrobial Peptide\n                    <i>DEFB1<\/i>\n                    Is Associated with Caries"],"prefix":"10.1177","volume":"89","author":[{"given":"A.","family":"Ozturk","sequence":"first","affiliation":[{"name":"Department of Periodontics and Preventive Dentistry, School of Dental Medicine, University of Pittsburgh"},{"name":"Department of Periodontics, Ondokuz Mayis University School of Dental Medicine, Kurupelit, Samsun, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Famili","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Preventive Dentistry, School of Dental Medicine, University of Pittsburgh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.R.","family":"Vieira","sequence":"additional","affiliation":[{"name":"Departments of Oral Biology, Pediatric Dentistry and Center for Craniofacial and Dental Genetics, School of Dental Medicine, and Department of Human Genetics, Graduate School of Public Health, and Clinical and Translational Science Institute, University of Pittsburgh, 614 Salk Hall, 3501 Terrace St., Pittsburgh, PA 15261, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,4,6]]},"reference":[{"key":"bibr1-0022034510364491","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.11.4.766-769.2004"},{"key":"bibr2-0022034510364491","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508401115"},{"key":"bibr3-0022034510364491","doi-asserted-by":"publisher","DOI":"10.2174\/138161207782110435"},{"key":"bibr4-0022034510364491","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(93)90106-V"},{"key":"bibr5-0022034510364491","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(01)00442-2"},{"key":"bibr6-0022034510364491","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2001.300305.x"},{"key":"bibr7-0022034510364491","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/10618600.1996.10474713","volume":"5","author":"Ihaka G","year":"1996","journal-title":"J Comp Graphic Stat"},{"key":"bibr8-0022034510364491","doi-asserted-by":"publisher","DOI":"10.1089\/10906570260471787"},{"key":"bibr9-0022034510364491","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2005.00136.x"},{"key":"bibr10-0022034510364491","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.9.4222-4228.1998"},{"key":"bibr11-0022034510364491","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2006.00909.x"},{"key":"bibr12-0022034510364491","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/49.1.49"},{"key":"bibr13-0022034510364491","doi-asserted-by":"crossref","first-page":"75","DOI":"10.14219\/jada.archive.1982.0054","volume":"105","author":"Liss J","year":"1982","journal-title":"J Am Dent Assoc"},{"key":"bibr14-0022034510364491","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.6.2740-2745.1999"},{"key":"bibr15-0022034510364491","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.11.1699"},{"key":"bibr16-0022034510364491","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3544"},{"key":"bibr17-0022034510364491","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki103"},{"key":"bibr18-0022034510364491","unstructured":"PA Department of Health (2002). Status of oral health in Pennsylvania. p. 51. 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