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The aim of this study was to determine whether PAR-2 expression and activation were increased in dental caries. Using immunohistochemistry, we showed PAR-2 to be localized to pulp cells subjacent to caries lesions, but minimally expressed by healthy pulp tissue. Trypsin and the PAR-2 agonist (PAR2-AP) activated PAR-2 in an in vitro functional assay. Endogenous molecules present in pulp cell lysates from carious teeth specifically activated PAR-2, but those from healthy teeth failed to do so. The activation of PAR-2 in vitro was shown to increase the expression of the pro-inflammatory mediator cyclo-oxygenase-2 (COX-2), providing a mechanism whereby PAR-2 could modulate pulpal inflammation.<\/jats:p>","DOI":"10.1177\/0022034510365652","type":"journal-article","created":{"date-parts":[[2010,5,26]],"date-time":"2010-05-26T22:56:07Z","timestamp":1274914567000},"page":"684-688","source":"Crossref","is-referenced-by-count":14,"title":["PAR-2 Regulates Dental Pulp Inflammation Associated with Caries"],"prefix":"10.1177","volume":"89","author":[{"given":"F.T.","family":"Lundy","sequence":"first","affiliation":[{"name":"Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Whitla Medical Building, Queen\u2019s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"About","sequence":"additional","affiliation":[{"name":"Laboratoire Interface Matrice 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