{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:42:37Z","timestamp":1777812157145,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2010,5,6]],"date-time":"2010-05-06T00:00:00Z","timestamp":1273104000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:p>Important factors involved in odontogenesis in mouse dental papillae disappear between the pre- and post-natal stages of development. Therefore, we hypothesized that certain genes involved in odontogenesis in dental papillae were subject to pre-\/post-natal down-regulation. Our goal was to identify, by microarray analysis, which genes were down-regulated. Dental papillae were isolated from embryonic 16-day-, 18-day- (E16, E18), and post-natal 3-day-old (P3) murine first mandibular molar germs and analyzed by microarray. The number of down-regulated genes was 2269 between E16 and E18, and 3130 between E18 and P3. Drastic down-regulation (fold change &gt; 10.0) of Adamts4, Aldha1a2, and Lef1 was observed at both E16 and E18, and quantitative RT-PCR revealed a post-natal reduction in their expression ( Adamts4, 1\/3; Aldh1a2, 1\/13; and Lef1, 1\/37). These results suggest that down-regulation of these three genes is an important factor in normal odontogenesis in dental papillae.<\/jats:p>","DOI":"10.1177\/0022034510366844","type":"journal-article","created":{"date-parts":[[2010,5,6]],"date-time":"2010-05-06T22:41:28Z","timestamp":1273185688000},"page":"679-683","source":"Crossref","is-referenced-by-count":9,"title":["Down-regulated Genes in Mouse Dental Papillae and Pulp"],"prefix":"10.1177","volume":"89","author":[{"given":"H.","family":"Sasaki","sequence":"first","affiliation":[{"name":"Oral Health Science Center HRC7, Tokyo Dental College, Japan"},{"name":"Department of Pathology, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba, 261-8502, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Muramatsu","sequence":"additional","affiliation":[{"name":"Oral Health Science Center HRC7, Tokyo Dental College, Japan"},{"name":"Department of Pathology, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba, 261-8502, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.-J.","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Oral Science Research Center, College of Dentistry, Brain Korea 21 Project for Medical Science, Yonsei University, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Histology, Cytology and Developmental Anatomy, Nihon University, School of Dentistry at Matsudo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Oral Health Science Center HRC7, Tokyo Dental College, Japan"},{"name":"Department of Pathology, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba, 261-8502, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.-S.","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba, 261-8502, Japan"},{"name":"Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Oral Science Research Center, College of Dentistry, Brain Korea 21 Project for Medical Science, Yonsei University, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Shimono","sequence":"additional","affiliation":[{"name":"Oral Health Science Center HRC7, Tokyo Dental College, Japan"},{"name":"Department of Pathology, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba, 261-8502, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,5,6]]},"reference":[{"key":"bibr1-0022034510366844","doi-asserted-by":"publisher","DOI":"10.3109\/03008209509013723"},{"key":"bibr2-0022034510366844","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-0436.1994.5730195.x"},{"key":"bibr3-0022034510366844","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0854.2004.00686.x"},{"key":"bibr4-0022034510366844","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.2006.00153.x"},{"key":"bibr5-0022034510366844","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-003-0311-z"},{"key":"bibr6-0022034510366844","doi-asserted-by":"publisher","DOI":"10.1177\/154405910208101005"},{"key":"bibr7-0022034510366844","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(80)90004-7"},{"key":"bibr8-0022034510366844","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(99)00322-6"},{"key":"bibr9-0022034510366844","first-page":"276","volume":"63","author":"Jones DM","year":"2008","journal-title":"S Afr Dent J"},{"key":"bibr10-0022034510366844","first-page":"159","volume":"24","author":"Kollar EJ","year":"1970","journal-title":"J Embryol Exp Morphol"},{"key":"bibr11-0022034510366844","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.11.1382"},{"key":"bibr12-0022034510366844","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1035602"},{"key":"bibr13-0022034510366844","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(94)90015-9"},{"key":"bibr14-0022034510366844","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.1.556"},{"key":"bibr15-0022034510366844","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.9.2271"},{"key":"bibr16-0022034510366844","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(87)90055-0"},{"key":"bibr17-0022034510366844","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003875200"},{"key":"bibr18-0022034510366844","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(96)00653-3"},{"key":"bibr19-0022034510366844","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(01)00561-5"},{"key":"bibr20-0022034510366844","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(87)90022-7"},{"key":"bibr21-0022034510366844","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.10.021"},{"key":"bibr22-0022034510366844","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-005-5534-2"},{"key":"bibr23-0022034510366844","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00410"},{"key":"bibr24-0022034510366844","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001065200"},{"key":"bibr25-0022034510366844","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.22.2691"},{"key":"bibr26-0022034510366844","doi-asserted-by":"publisher","DOI":"10.1042\/bj20030896"},{"key":"bibr27-0022034510366844","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1996.0015h.x"}],"container-title":["Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0022034510366844","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0022034510366844","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0022034510366844","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:05:53Z","timestamp":1777496753000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0022034510366844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,6]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.1177\/0022034510366844"],"URL":"https:\/\/doi.org\/10.1177\/0022034510366844","relation":{},"ISSN":["0022-0345","1544-0591"],"issn-type":[{"value":"0022-0345","type":"print"},{"value":"1544-0591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,6]]}}}