{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:42:54Z","timestamp":1777812174187,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2010,4,16]],"date-time":"2010-04-16T00:00:00Z","timestamp":1271376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:p>Interleukin-17 (IL-17), the prototype cytokine produced by the Th17 subset of T-helper cells, plays a role in inflammatory responses, autoimmunity, and antimicrobial responses in a variety of infectious and inflammatory diseases. In view of the inflammatory nature and severity of aggressive periodontitis, we hypothesized that IL-17 might be detected in sera from patients with aggressive periodontitis. We used ELISA to measure IL-17 serum concentrations from 67 periodontally healthy (NP) individuals and from 53 patients with localized (LAgP) and 49 patients with generalized (GAgP) aggressive periodontitis. IL-17 was barely detectable in sera from periodontally healthy individuals (1.9 \u00b1 2.0 pg\/mL), but was present at significantly higher concentrations in sera from those with LAgP (7.6 \u00b1 2.2 pg\/mL) and GAgP (17.1 \u00b1 2.3 pg\/mL). Multivariate analyses demonstrated associations of IL-17 concentrations with periodontal attachment loss, but not with current smoking. Therefore, Th17 responses may be characteristic of AgP, and IL-17 may play a role in the pathogenesis of aggressive periodontitis.<\/jats:p>","DOI":"10.1177\/0022034510369297","type":"journal-article","created":{"date-parts":[[2010,4,16]],"date-time":"2010-04-16T22:22:59Z","timestamp":1271456579000},"page":"943-947","source":"Crossref","is-referenced-by-count":77,"title":["IL-17 in Sera from Patients with Aggressive Periodontitis"],"prefix":"10.1177","volume":"89","author":[{"given":"H.A.","family":"Schenkein","sequence":"first","affiliation":[{"name":"Departments of Periodontics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.E.","family":"Koertge","sequence":"additional","affiliation":[{"name":"Departments of Periodontics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.N.","family":"Brooks","sequence":"additional","affiliation":[{"name":"General Practice, School of Dentistry, Virginia Commonwealth University, Richmond, VA 23298-0566, 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