{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:14:34Z","timestamp":1790367274796,"version":"4.1.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2010,6,4]],"date-time":"2010-06-04T00:00:00Z","timestamp":1275609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:p>\n                    Early detection of oral premalignant lesions (OPMLs) by visual inspection with toluidine blue has not been addressed. We conducted a community-based randomized controlled trial to assess whether using toluidine blue as an adjunctive tool for visual screening had a higher detection rate of OPMLs and could further reduce the incidence of oral cancer. In 2000, in Keelung, we randomly assigned a total of 7975 individuals, aged 15 years or older and with high-risk oral habits, to either the toluidine-blue-screened (TBS) group or the visual screening group. Results showed 5% more oral premalignant lesions and 79% more oral submucous fibrosis detected in the TBS group than in the control group. After a five-year follow-up ascertaining oral cancer development through linkage to the National Cancer Registry, the incidence rate in the TBS group (28.0 x 10\n                    <jats:sup>\u22125<\/jats:sup>\n                    ) was non-significantly 21% lower than that in the control group (35.4 x 10\n                    <jats:sup>\u22125<\/jats:sup>\n                    ).\n                  <\/jats:p>","DOI":"10.1177\/0022034510373763","type":"journal-article","created":{"date-parts":[[2010,6,4]],"date-time":"2010-06-04T22:52:44Z","timestamp":1275691964000},"page":"933-937","source":"Crossref","is-referenced-by-count":42,"title":["A Community-based RCT for Oral Cancer Screening with Toluidine Blue"],"prefix":"10.1177","volume":"89","author":[{"given":"W.W.-Y.","family":"Su","sequence":"first","affiliation":[{"name":"Division of Biostatistics, Graduate Institute of Epidemiology\/Centre of Biostatistics Consultation, College of Public Health, National Taiwan University, Room 533, No. 17, Hsu-chow Road, Taipei, 100, Taiwan"},{"name":"Department of Otolaryngology Head and Neck Surgery, Buddhist Tzu Chi General Hospital, Taipei Branch, Taipei, Taiwan"},{"name":"School of Medicine, Tzu Chi University, Hualien, Taiwan, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.-F.","family":"Yen","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Graduate Institute of Epidemiology\/Centre of Biostatistics Consultation, College of Public Health, National Taiwan University, Room 533, No. 17, Hsu-chow Road, Taipei, 100, Taiwan"},{"name":"Centre of Biostatistics Consultation, College of Public Health, National Taiwan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.Y.-H.","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department and Graduate Institute of Health Care Management, Chang Gung University, Tao-Yuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.H.-H.","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Graduate Institute of Epidemiology\/Centre of Biostatistics Consultation, College of Public Health, National Taiwan University, Room 533, No. 17, Hsu-chow Road, Taipei, 100, Taiwan"},{"name":"Centre of Biostatistics Consultation, College of Public Health, National Taiwan 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