{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:43:06Z","timestamp":1777812186642,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2010,6,8]],"date-time":"2010-06-08T00:00:00Z","timestamp":1275955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:p>\n                    No evidence for the role of protease-activated receptor-2 (PAR\n                    <jats:sub>2<\/jats:sub>\n                    ) in human periodontal disease has been demonstrated so far. Thus, we sought to investigate the expression of PAR\n                    <jats:sub>2<\/jats:sub>\n                    mRNA in chronic periodontitis, and to examine whether its expression is related to the presence of PAR\n                    <jats:sub>2<\/jats:sub>\n                    potential activators. Microbiological and gingival crevicular fluid samples were collected from individuals with chronic periodontitis and control individuals, and the presence of neutrophil serine proteinase 3 (P3) and Porphyromonas gingivalis was evaluated. PAR\n                    <jats:sub>2<\/jats:sub>\n                    mRNA expression was higher (p &lt; 0.001) in those with chronic periodontitis compared with control individuals, and it was statistically decreased (p = 0.0006) after periodontal treatment. Furthermore, those with chronic periodontitis presented higher (p &lt; 0.05) levels of IL-1\u03b1, IL-6, IL-8, and TNF-\u03b1, total proteolytic activity, P. gingivalis prevalence, and P3mRNA expression compared with control individuals. We conclude that PAR\n                    <jats:sub>2<\/jats:sub>\n                    mRNA expression and its potential activators are elevated in human chronic periodontitis, therefore suggesting that PAR\n                    <jats:sub>2<\/jats:sub>\n                    may play a role in periodontal inflammation.\n                  <\/jats:p>","DOI":"10.1177\/0022034510373765","type":"journal-article","created":{"date-parts":[[2010,6,8]],"date-time":"2010-06-08T22:46:43Z","timestamp":1276037203000},"page":"948-953","source":"Crossref","is-referenced-by-count":32,"title":["Protease-activated Receptor-2 (par\n                    <sub>2<\/sub>\n                    ) in Human Periodontitis"],"prefix":"10.1177","volume":"89","author":[{"given":"M.","family":"Holzhausen","sequence":"first","affiliation":[{"name":"Division of Periodontics, Department of Stomatology, School of Dentistry, University of S\u00e3o Paulo, S\u00e3o Paulo, SP, Avenida Prof. Lineu Prestes, 2227, Cidade Universit\u00e1ria, S\u00e3o Paulo-SP, CEP: 05508-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.R.","family":"Cortelli","sequence":"additional","affiliation":[{"name":"Division of Periodontics, Department of Stomatology, School of Dentistry, University of S\u00e3o Paulo, S\u00e3o Paulo, SP, Avenida Prof. Lineu Prestes, 2227, Cidade Universit\u00e1ria, S\u00e3o Paulo-SP, CEP: 05508-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. Ara\u00fajo","family":"da Silva","sequence":"additional","affiliation":[{"name":"Division of Periodontics, Department of Stomatology, School of Dentistry, University of S\u00e3o Paulo, S\u00e3o Paulo, SP, Avenida Prof. Lineu Prestes, 2227, Cidade Universit\u00e1ria, S\u00e3o Paulo-SP, CEP: 05508-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.C. Nobre","family":"Franco","sequence":"additional","affiliation":[{"name":"Division of Periodontics, Department of Stomatology, School of Dentistry, University of S\u00e3o Paulo, S\u00e3o Paulo, SP, Avenida Prof. Lineu Prestes, 2227, Cidade Universit\u00e1ria, S\u00e3o Paulo-SP, CEP: 05508-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Cavalca","family":"Cortelli","sequence":"additional","affiliation":[{"name":"Division of Periodontics, Department of Stomatology, School of Dentistry, University of S\u00e3o Paulo, S\u00e3o Paulo, SP, Avenida Prof. Lineu Prestes, 2227, Cidade Universit\u00e1ria, S\u00e3o Paulo-SP, CEP: 05508-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Vergnolle","sequence":"additional","affiliation":[{"name":"INSERM U563, Centre de Physiopathologie de Toulouse Purpan, Toulouse, F-31300, France"},{"name":"Universit\u00e9 de Toulouse III Paul Sabatier, Toulouse, F-31000, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,6,8]]},"reference":[{"key":"bibr1-0022034510373765","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(99)00237-9"},{"key":"bibr2-0022034510373765","first-page":"1","volume":"8","author":"Attstr\u00f6m R","year":"1971","journal-title":"J Periodontal Res 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