{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:54:37Z","timestamp":1792684477715,"version":"4.5.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2010,8,25]],"date-time":"2010-08-25T00:00:00Z","timestamp":1282694400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:p>Periodontal infections have been associated with a state of chronic inflammation. To ascertain whether severe periodontitis and its treatment are associated with oxidative stress, we recruited 145 cases (periodontitis) and 56 controls in a case-control study. A further pilot intervention study of 14 cases (periodontal therapy) was performed. Blood samples were taken at baseline (case-control) and 1, 3, 5, 7, and 30 days after treatment (intervention). Diacron-reactive oxygen metabolites (D-ROM), anti-oxidant potential, C-reactive protein (CRP), interleukin-6, and lipid profiles were determined with high-sensitivity assays in serum. Patients with severe periodontitis exhibited higher D-ROM levels (P &lt; 0.001) and lower total anti-oxidant capacity (P &lt; 0.001) compared with healthy control individuals. These findings were independent of age, gender, smoking habits, ethnicity, and standard lipids differences. D-ROM levels were positively correlated with CRP (R = 0.4, P &lt; 0.001) and clinical periodontal parameters (R = 0.20, P &lt; 0.05). Acute increases of D-ROM (P &lt; 0.01) were observed following periodontal therapy. Analysis of these data suggests a positive association between severe periodontitis and oxidative stress.<\/jats:p>","DOI":"10.1177\/0022034510375830","type":"journal-article","created":{"date-parts":[[2010,8,25]],"date-time":"2010-08-25T22:39:32Z","timestamp":1282775972000},"page":"1241-1246","source":"Crossref","is-referenced-by-count":275,"title":["Oxidative Stress, Systemic Inflammation, and Severe Periodontitis"],"prefix":"10.1177","volume":"89","author":[{"given":"F.","family":"D\u2019Aiuto","sequence":"first","affiliation":[{"name":"Periodontology Unit, Division of Clinical Research, UCL Eastman Dental Institute and Hospital, 256 Gray\u2019s Inn Road, London WC1X 8LD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Nibali","sequence":"additional","affiliation":[{"name":"Periodontology Unit, Division of Clinical Research, UCL Eastman Dental Institute and Hospital, 256 Gray\u2019s Inn Road, London WC1X 8LD, 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