{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:40:17Z","timestamp":1777812017364,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2010,7,20]],"date-time":"2010-07-20T00:00:00Z","timestamp":1279584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:p>Synovitis, which is characterized by the infiltration of inflammatory cells, often accompanies progression of temporomandibular joint disorder (TMD) symptoms. Because IL-1\u03b2 is elevated in synovial fluids obtained from TMDs, we hypothesized that IL-1\u03b2-responsive genes in synoviocytes may help identify the putative genes associated with synovitis. Using microarray analysis, we found that monocyte chemoattractant protein-1 (MCP-1) mRNA levels were elevated in IL-1\u03b2-stimulated synoviocytes. MCP-1 is a member of the chemokine superfamily. The production of MCP-1 was increased in synoviocytes treated with IL-1\u03b2. When IL-1\u03b2 was injected into the cavities of rat TMJs, inflammatory cells and MCP-1-positive cells were detected in the synovial tissues. Furthermore, MCP-1 levels were higher in synovial fluids from individuals with pain compared with those without pain. Inhibitors of MAP-kinases and NF-\u03baB reduced IL-1\u03b2-induced MCP-1 production. These results suggest that MCP-1 stimulated by IL-1\u03b2 is one of the factors associated with the inflammatory progression of TMDs.<\/jats:p>","DOI":"10.1177\/0022034510376041","type":"journal-article","created":{"date-parts":[[2010,7,20]],"date-time":"2010-07-20T23:13:41Z","timestamp":1279667621000},"page":"1117-1122","source":"Crossref","is-referenced-by-count":55,"title":["MCP-1 Production in Temporomandibular Joint Inflammation"],"prefix":"10.1177","volume":"89","author":[{"given":"N.","family":"Ogura","sequence":"first","affiliation":[{"name":"Department of Maxillofacial Surgery, Nihon University School of Dentistry at Matsudo, 2\u2013870\u20131 Sakaecho-Nishi, Matsudo, Chiba 271\u20138587, Japan"},{"name":"Research Institute of Oral Science, Nihon University School of Dentistry at Matsudo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Satoh","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery, Nihon University 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