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We established a protocol for rat mandible and long-bone marrow stromal cell (BMSC) isolation and culture. Mandible BMSC cultures formed more colonies, suggesting an increased CFU-F population. Both mandible and long-bone BMSCs differentiated into osteoblasts. However, mandible BMSCs demonstrated augmented alkaline phosphatase activity, mineralization, and osteoblast gene expression. Importantly, upon implantation into nude mice, mandible BMSCs formed 70% larger bone nodules containing three-fold more mineralized bone compared with long-bone BMSCs. Analysis of these data demonstrates an increased osteogenic potential and augmented capacity of mandible BMSCs to induce bone formation in vitro and in vivo. Our findings support differences in the mechanisms underlying mandible homeostasis and the pathophysiology of diseases unique to the jaws.<\/jats:p>","DOI":"10.1177\/0022034510378427","type":"journal-article","created":{"date-parts":[[2010,9,2]],"date-time":"2010-09-02T00:35:38Z","timestamp":1283387738000},"page":"1293-1298","source":"Crossref","is-referenced-by-count":143,"title":["Osteogenic Potential of Mandibular\n                    <i>vs.<\/i>\n                    Long-bone Marrow Stromal Cells"],"prefix":"10.1177","volume":"89","author":[{"given":"T.L.","family":"Aghaloo","sequence":"first","affiliation":[{"name":"Division of Diagnostic and Surgical Sciences, UCLA School of Dentistry, 10833 LeConte Ave., CHS Rm. 53\u2013068, Los Angeles, CA 90095-1668, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Chaichanasakul","sequence":"additional","affiliation":[{"name":"Division of Diagnostic and Surgical Sciences, UCLA School of Dentistry, 10833 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