{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:00:57Z","timestamp":1790974857003,"version":"4.1.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2010,10,6]],"date-time":"2010-10-06T00:00:00Z","timestamp":1286323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:p>\n                    1\u03b125(OH)\n                    <jats:sub>2<\/jats:sub>\n                    vitaminD\n                    <jats:sub>3<\/jats:sub>\n                    and its nuclear receptor, VDR, are essential for normal tooth development. However, the relative contributions of the direct vs. indirect effects of vitamin D action on odontogenesis are unclear. The aim of this study was to discriminate among the specific roles of 1\u03b125(OH)\n                    <jats:sub>2<\/jats:sub>\n                    vitaminD\n                    <jats:sub>3<\/jats:sub>\n                    , calcemia\/phosphatemia, and the maternal environment in mouse VDR null mutants. Microradiographic, histological, and molecular analyses were conducted on adult mice under hypocalcemic\/hypophosphatemic vs. normocalcemic\/normophosphatemic conditions, and pups of first- (VDR-\/- born to VDR+\/- dams) vs. second-generation (VDR-\/- born to VDR-\/- dams) mice. In VDR-\/- mice, crown morphogenesis was affected exclusively in second-generation pups. In first-generation adult VDR-\/- mice, both enamel and dentin were affected, and pathologic features of root resorption in both apical and cervical regions were observed. Nutritional calcium and phosphate normalization completely rescued the root resorption and partially rescued the dentin and enamel phenotypes (altered cell differentiation and matrix protein expression). Analysis of these data illustrates the co-existence of different pathways of vitamin D action in tooth differentiation and biomineralization. These targeted and cumulative effects would generate the diverse and wide spectrum of dental rickets phenotypes.\n                  <\/jats:p>","DOI":"10.1177\/0022034510379603","type":"journal-article","created":{"date-parts":[[2010,10,7]],"date-time":"2010-10-07T00:24:20Z","timestamp":1286411060000},"page":"1427-1432","source":"Crossref","is-referenced-by-count":29,"title":["Physiopathology of Dental Rickets in Vitamin D Receptor-ablated Mice"],"prefix":"10.1177","volume":"89","author":[{"given":"V.","family":"Descroix","sequence":"first","affiliation":[{"name":"Molecular Oral Physiopathology, INSERM UMRS872-IFR 58, Universities Paris 5, Paris 6, and Paris 7, Cordeliers Research Centre, Escalier E, 15 rue de l\u2019\u00e9cole de m\u00e9decine, 75270 Paris Cedex 06, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kato","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cellular Biosciences, Tokyo University, 1-1-1 Yayoi, Bunkyo, Tokyo 113\u20130032, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"L\u00e9zot","sequence":"additional","affiliation":[{"name":"Molecular Oral Physiopathology, INSERM UMRS872-IFR 58, Universities Paris 5, Paris 6, and Paris 7, Cordeliers Research Centre, Escalier E, 15 rue de l\u2019\u00e9cole de m\u00e9decine, 75270 Paris Cedex 06, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Berdal","sequence":"additional","affiliation":[{"name":"Molecular Oral Physiopathology, INSERM UMRS872-IFR 58, Universities Paris 5, Paris 6, and Paris 7, Cordeliers Research Centre, Escalier E, 15 rue de l\u2019\u00e9cole de m\u00e9decine, 75270 Paris Cedex 06, 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