{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T20:36:35Z","timestamp":1780950995532,"version":"3.54.1"},"reference-count":52,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>\n                    We hypothesized that tobacco smoke induces alterations to the 3-OH fatty acids present in lipid A in a manner consistent with a microflora of reduced inflammatory potential. Whole saliva samples and full-mouth clinical periodontal recordings were obtained from persons with (22 smokers; 15 non-smokers) and without (14 smokers; 15 non-smokers) chronic periodontitis. Clear differences in the contributions of multiple saturated 3-OH fatty acid species were noted in the group with disease compared with healthy individuals. Increases in the long-chain fatty acids associated with anaerobic bacterial periodontopathogens, particularly 3-OH-C\n                    <jats:sub>i17.0<\/jats:sub>\n                    (146.7%, relative to controls), were apparent. Significant reductions in the 3-OH fatty acids associated with the consensus (high potency) enteric LPS structure (3-OH-C\n                    <jats:sub>12.0<\/jats:sub>\n                    and 3-OH-C\n                    <jats:sub>14.0<\/jats:sub>\n                    ; 33.3% and 15.8% reduction, respectively) were noted in smokers compared with non-smokers with chronic periodontitis. Thus, smoking is associated with specific structural alterations to the lipid-A-derived 3-OH fatty acid profile in saliva that are consistent with an oral microflora of reduced inflammatory potential. These findings provide much-needed mechanistic insight into the established clinical conundrum of increased infection with periodontal pathogens but reduced clinical inflammation in smokers.\n                  <\/jats:p>","DOI":"10.1177\/0022034510380695","type":"journal-article","created":{"date-parts":[[2010,11,2]],"date-time":"2010-11-02T01:10:15Z","timestamp":1288660215000},"page":"47-52","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Fatty Acid Profiles in Smokers with Chronic Periodontitis"],"prefix":"10.1177","volume":"90","author":[{"given":"N.","family":"Buduneli","sequence":"first","affiliation":[{"name":"Department of Periodontology, School of Dentistry, Ege University, \u0130zmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Larsson","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Division of Medical Microbiology, Lund University, S\u00f6lvegatan 23, 223 62 Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"B\u0131y\u0131ko\u011flu","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry, Ege University, \u0130zmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.E.","family":"Renaud","sequence":"additional","affiliation":[{"name":"Oral Health and Systemic Disease Research Group, School of Dentistry, University of Louisville, 501 S. 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