{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T03:14:14Z","timestamp":1789528454450,"version":"build-2803163510"},"reference-count":26,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2010,10,12]],"date-time":"2010-10-12T00:00:00Z","timestamp":1286841600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:p>The aim of this study was to investigate the involvement of autoimmune reactions to native and post-translationally modified extracellular matrix components in the pathogenesis of periodontitis. Sera from individuals with aggressive periodontitis (AgP, n = 25), chronic periodontitis (CP, n = 14), and gingivitis (G, n = 18) were tested for the presence of autoantibodies against: (a) native collagen type I (CI) and collagen type III (CIII); (b) CI and CIII post-translationally modified by reactive oxygen species (ROS) of the type present during inflammation; and (c) citrullinated filaggrin-derived peptides (CCP). Autoantibodies to native and ROS-modified CI and CIII as well as autoantibodies to CCP were observed exclusively in patients with AgP and not in those with CP or G. In conclusion, autoimmune reactions to native and post-translationally modified self-antigens may play a role specifically in the pathogenesis of AgP.<\/jats:p>","DOI":"10.1177\/0022034510381903","type":"journal-article","created":{"date-parts":[[2010,10,13]],"date-time":"2010-10-13T03:23:17Z","timestamp":1286940197000},"page":"1389-1394","source":"Crossref","is-referenced-by-count":62,"title":["Involvement of Autoimmunity in the Pathogenesis of Aggressive Periodontitis"],"prefix":"10.1177","volume":"89","author":[{"given":"A.","family":"Hendler","sequence":"first","affiliation":[{"name":"Bone and Joint Research Unit"},{"name":"Faculty of Dental Medicine, The Hebrew University-Hadassah, PO Box 12272, Jerusalem 91120, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.K.","family":"Mulli","sequence":"additional","affiliation":[{"name":"Dental Institute, Kings College London, Floor 21 Tower Wing, Guys Hospital, Great Maze Pond, London SE1 9RT, 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