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Modified Widman periodontal surgery was performed, during which 200 \u00b5L of the investigational formulation containing 0% (vehicle alone), 0.2%, 0.3%, or 0.4% FGF-2 was administered to 2- or 3-walled vertical bone defects. Each dose of FGF-2 showed significant superiority over vehicle alone (p &lt; 0.01) for the percentage of bone fill at 36 wks after administration, and the percentage peaked in the 0.3% FGF-2 group. No significant differences among groups were observed in clinical attachment regained, scoring approximately 2 mm. No clinical safety problems, including an abnormal increase in alveolar bone or ankylosis, were identified. These results strongly suggest that topical application of FGF-2 can be efficacious in the regeneration of human periodontal tissue that has been destroyed by periodontitis.<\/jats:p>","DOI":"10.1177\/0022034510384616","type":"journal-article","created":{"date-parts":[[2010,11,8]],"date-time":"2010-11-08T23:48:21Z","timestamp":1289260101000},"page":"35-40","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":223,"title":["FGF-2 Stimulates Periodontal Regeneration"],"prefix":"10.1177","volume":"90","author":[{"given":"M.","family":"Kitamura","sequence":"first","affiliation":[{"name":"Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Dental Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Akamatsu","sequence":"additional","affiliation":[{"name":"Clinical Development Department, Kaken Pharmaceutical Co., 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