{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:02:31Z","timestamp":1791252151524,"version":"4.1.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2011,1,6]],"date-time":"2011-01-06T00:00:00Z","timestamp":1294272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:p>\n                    The nitric oxide (NO) receptor enzyme soluble guanylate cyclase (sGC) contains one prosthetic heme group as an \u03b1\u03b2 heterodimer, and two heterodimer isoforms (\u03b1\n                    <jats:sub>1<\/jats:sub>\n                    \u03b2\n                    <jats:sub>1<\/jats:sub>\n                    , \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    \u03b2\n                    <jats:sub>1<\/jats:sub>\n                    ) were characterized to have enzyme activity. To test the irreversible inflammation-dependent regulation of sGC in odontoblasts, we incubated decalcified frozen sections of healthy and inflamed human third molars with antibodies against \u03b2-actin, nitrotyrosine, inducible nitric oxide synthase (iNOS), \u03b1\n                    <jats:sub>1<\/jats:sub>\n                    -, \u03b2\n                    <jats:sub>1<\/jats:sub>\n                    -, and \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    -subunits of sGC and analyzed them at protein levels by quantitative immunohistochemistry. The irreversible inflammation induced an increase in the signal intensities for nitrotyrosine and iNOS and a decrease for the \u03b1\n                    <jats:sub>1<\/jats:sub>\n                    -, \u03b2\n                    <jats:sub>1<\/jats:sub>\n                    -, and \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    -subunits of sGC in odontoblasts. Inflammatory mediators, reactive oxygen, and nitrogen species may impair the expression of the \u03b1\n                    <jats:sub>1<\/jats:sub>\n                    -, \u03b2\n                    <jats:sub>1<\/jats:sub>\n                    -, and \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    -subunits in odontoblasts. The decrease of sGC at the protein level in inflamed odontoblasts is compatible with a critical role for sGC to mediate biological effects of NO in health.\n                  <\/jats:p>","DOI":"10.1177\/0022034510390808","type":"journal-article","created":{"date-parts":[[2011,1,6]],"date-time":"2011-01-06T23:40:41Z","timestamp":1294357241000},"page":"517-522","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Irreversible Inflammation is Associated with Decreased Levels of the \u03b1\n                    <sub>1<\/sub>\n                    -, \u03b2\n                    <sub>1<\/sub>\n                    -, and \u03b1\n                    <sub>2<\/sub>\n                    -Subunits of sGC in Human Odontoblasts"],"prefix":"10.1177","volume":"90","author":[{"given":"Y.","family":"Korkmaz","sequence":"first","affiliation":[{"name":"Department of Operative Dentistry, Periodontics and Endodontics, Heinrich-Heine-University, Moorenstrasse 5, 40225 D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry and Periodontology, University of Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Beikler","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry, Periodontics and Endodontics, Heinrich-Heine-University, Moorenstrasse 5, 40225 D\u00fcsseldorf, Germany"},{"name":"Department of Periodontics, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry, Periodontics and Endodontics, Heinrich-Heine-University, Moorenstrasse 5, 40225 D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Behrends","sequence":"additional","affiliation":[{"name":"Institute for Pharmacology, Toxicology and Clinical Pharmacy, Technical University of Carolo-Wilhelmina at Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Bloch","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Sport Medicine, German Sport University, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Addicks","sequence":"additional","affiliation":[{"name":"Department I of Anatomy, University of Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.H.-M.","family":"Raab","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry, Periodontics and Endodontics, Heinrich-Heine-University, Moorenstrasse 5, 40225 D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,1,6]]},"reference":[{"key":"bibr1-0022034510390808","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2007.11.004"},{"key":"bibr2-0022034510390808","first-page":"909","volume":"86","author":"Bamberger AM","year":"2001","journal-title":"J Clin Endocrinol 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