{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:08:28Z","timestamp":1791277708356,"version":"4.1.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2011,3,10]],"date-time":"2011-03-10T00:00:00Z","timestamp":1299715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p>The aim of the present study was to clarify the involvement of protein kinase C\u03b3 (PKC\u03b3) in the facial neuropathic pain following infraorbital nerve injury. We analyzed the change in PKC\u03b3 expression in the trigeminal spinal subnucleus caudalis (Vc) and upper cervical spinal cord (C1\/C2) following chronic constriction injury of the infraorbital nerve (ION-CCI). We also studied ION-CCI-mediated mechanical nocifensive behavior in rats. The mechanical head-withdrawal threshold significantly decreased 1 to 14 days after ION-CCI compared with that before ION-CCI and in sham rats. The expression of PKC\u03b3 was significantly larger in the ipsilateral Vc compared with the contralateral side in ION-CCI rats 3, 7, and 14 days after ION-CCI. Intrathecal (i.t.) administration of the PKC\u03b3 inhibitor chelerythrine prevented an increase in the PKC\u03b3 expression in the ipsilateral Vc. Moreover, i.t. administration of chelerythrine annulled ION-CCI-mediated reduction in the head-withdrawal threshold. Taken together, these findings suggest that PKC\u03b3 expression in the Vc played an important role in the mechanism of orofacial static mechanical allodynia following trigeminal nerve injury.<\/jats:p>","DOI":"10.1177\/0022034511401406","type":"journal-article","created":{"date-parts":[[2011,3,10]],"date-time":"2011-03-10T22:50:40Z","timestamp":1299797440000},"page":"777-781","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["PKC\u03b3 in Vc and C1\/C2 is Involved in Trigeminal Neuropathic Pain"],"prefix":"10.1177","volume":"90","author":[{"given":"A.","family":"Nakajima","sequence":"first","affiliation":[{"name":"Department of Orthodontics\u00a0 Division of Functional Morphology, Dental Research Center,\u00a0"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Tsuboi","sequence":"additional","affiliation":[{"name":"Division of Functional Morphology, Dental Research 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