{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:21:10Z","timestamp":1792110070900,"version":"4.4.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2011,3,15]],"date-time":"2011-03-15T00:00:00Z","timestamp":1300147200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p>Hypersensitivity to thermal and mechanical stimuli can occur in painful pulpitis. To explore the neuro-anatomical basis of heat and mechanical sensitivity, we evaluated expression of TRPV1 (heat) and TRPV2 (heat\/mechanical) channels in the cell bodies and terminal arborizations of neurons that innervate the dental pulp (DP) and periodontal tissues (PDL). We report that ~50% of trigeminal ganglion (TG) neurons retrogradely labeled from the DP express TRPV2, and this was significantly greater than the general expression of this channel in the TG (15%) and slightly more than what is expressed in the PDL by retrograde labeling (40%). The TRPV1 receptor, however, was less prevalent in neurons innervating the DP than their general expression in the TG (17% vs. 26%) and was more extensively expressed in neurons innervating the PDL (26%). Co-labeling studies showed that 70% of neurons that innervate the DP are myelinated. Approximately 1\/3 of the retrogradely labeled neurons from the DP were calcitonin-gene-related-peptide-positive (peptide-expressing), but very few expressed the IB4 marker of non-peptidergic unmyelinated afferents. These findings suggest that the DP has a unique neurochemical innervation with regard to TRP receptor expression, which has significant implications for the mechanisms contributing to odontogenic pain and management strategies.<\/jats:p>","DOI":"10.1177\/0022034511402206","type":"journal-article","created":{"date-parts":[[2011,3,16]],"date-time":"2011-03-16T00:01:05Z","timestamp":1300233665000},"page":"765-770","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":87,"title":["Differential TRPV1 and TRPV2 Channel Expression in Dental Pulp"],"prefix":"10.1177","volume":"90","author":[{"given":"J.L.","family":"Gibbs","sequence":"first","affiliation":[{"name":"Department of Preventive and Restorative Dental Sciences, University of California San Francisco\u00a0  \u00a0jlg15@nyu.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.L.","family":"Melnyk","sequence":"additional","affiliation":[{"name":"Department of Preventive and Restorative Dental Sciences, University of California San Francisco\u00a0"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.I.","family":"Basbaum","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University of California San Francisco, San Francisco, CA 94158, USA\u00a0"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,3,15]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4863-05.2006"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(86)80198-4"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1038\/39807"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1038\/18906"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5464.306"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0901507106"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(83)90083-X"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80813-2"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1054\/jpai.2001.26173"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1177\/00220345010800060801"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1053\/eujp.2001.0305"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(65)90350-6"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.03.027"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808701008"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02042-4"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)03253-4"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1177\/00220345970760070301"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00908-X"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2007.12.001"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20024"},{"key":"atypb21","first-page":"248","volume":"19","year":"2005","journal-title":"J Orofac Pain"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000097263.10220.0C"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1982.tb07062.x"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2007.01.023"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(03)00071-2"},{"key":"atypb26","unstructured":"Park\u00a0UV,Guan\u00a0Y,Raja\u00a0SN,Koltzenburg\u00a0M,Caterina\u00a0MJEdinburgh, Scotland: International Association for the Study of Pain; 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