{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:11:05Z","timestamp":1783015865902,"version":"3.54.6"},"reference-count":16,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2011,7,5]],"date-time":"2011-07-05T00:00:00Z","timestamp":1309824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p>While much research has focused on local and systemic factors contributing to periodontal disease, little is known regarding mechanisms linking these factors. We have previously reported a systemic hyper-inflammatory response to bacterial endotoxin in localized aggressive periodontitis (LAP). The objectives of this study were to delineate cyto\/chemokines in gingival crevicular fluid (GCF) and evaluate systemic levels of endotoxin associated with LAP. Clinical parameters, GCF, and peripheral blood were collected from: 34 LAP, 10 healthy siblings, and nine healthy unrelated control individuals. Cyto\/chemokines were quantified in GCF, systemic endotoxin levels were quantified in plasma, and correlation analysis was performed among all parameters. Nine mediators were elevated in LAP diseased sites as compared with healthy sites (TNF\u03b1, INF\u03b3, IL1\u03b2, IL2, IL6, IL10, Il12p40, GMCSF, and MIP1\u03b1, p &lt; 0.001), while MCP1, IL4, and IL8 were elevated in healthy sites (p &lt; 0.01). Four- to five-fold-higher endotoxin levels were detected in LAP plasma compared with that from healthy participants (p &lt; 0.0001), which correlated with all clinical parameters and most cyto\/chemokines analyzed. In conclusion, higher systemic levels of endotoxin were found in LAP, which correlates with an exacerbated local inflammatory response and clinical signs of disease. (Clinicaltrials.gov number, NCT01330719).<\/jats:p>","DOI":"10.1177\/0022034511413928","type":"journal-article","created":{"date-parts":[[2011,7,6]],"date-time":"2011-07-06T00:02:09Z","timestamp":1309910529000},"page":"1140-1144","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":81,"title":["Local Inflammatory Markers and Systemic Endotoxin in Aggressive Periodontitis"],"prefix":"10.1177","volume":"90","author":[{"given":"L.M.","family":"Shaddox","sequence":"first","affiliation":[{"name":"Department of Periodontology, University of Florida College of Dentistry, PO Box 100434, Gainesville, FL 32610-0434, USA, Department of Oral Biology, University of Florida College of Dentistry\r\u00a0lshaddox@dental.ufl.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Wiedey","sequence":"additional","affiliation":[{"name":"Department of Periodontology, University of Florida College of Dentistry, PO Box 100434, Gainesville, FL 32610-0434, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.L.","family":"Calderon","sequence":"additional","affiliation":[{"name":"Department of Periodontology, University of Florida College of Dentistry, PO Box 100434, Gainesville, FL 32610-0434, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Magnusson","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, University of Florida College of Dentistry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Bimstein","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, University of Florida College of Dentistry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.A.","family":"Bidwell","sequence":"additional","affiliation":[{"name":"Leon County Health Department, Tallahassee, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.F.","family":"Zapert","sequence":"additional","affiliation":[{"name":"Leon County Health Department, Tallahassee, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Aukhil","sequence":"additional","affiliation":[{"name":"Department of Periodontology, University of Florida College of Dentistry, PO Box 100434, Gainesville, FL 32610-0434, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.M.","family":"Wallet","sequence":"additional","affiliation":[{"name":"Department of Periodontology, University of Florida College of Dentistry, PO Box 100434, Gainesville, FL 32610-0434, USA, Department of Oral Biology, University of Florida College of 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