{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:45:01Z","timestamp":1789735501429,"version":"4.0.1"},"reference-count":35,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2011,7,5]],"date-time":"2011-07-05T00:00:00Z","timestamp":1309824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p>The mineral and organic phases of mineralized dentin contribute co-operatively to its strength and toughness. This study tested the null hypothesis that there is no difference in nano-dynamic mechanical behavior (complex modulus-E*; loss modulus-E\u2032\u2032; storage modulus-E\u2032; in GPa) of dentin hybrid layers (baseline: E*, 3.86 \u00b1 0.24; E\u2032\u2032, 0.23 \u00b1 0.05; E\u2032, 3.85 \u00b1 0.24) created by an etch-and-rinse adhesive in the presence or absence of biomimetic remineralization after in vitro aging. Using scanning probe microscopy and nano-dynamic mechanical analysis, we demonstrated that biomimetic remineralization restored the nano-dynamic mechanical behavior of heavily remineralized, resin-sparse regions of dentin hybrid layers (E*, 19.73 \u00b1 3.85; E\u2032\u2032, 8.75 \u00b1 3.97; E\u2032, 16.02 \u00b1 2.58) to those of the mineralized dentin base (E*, 19.20 \u00b1 2.42; E\u2032\u2032, 6.57 \u00b1 1.96; E\u2032, 17.39 \u00b1 2.0) [p &gt; 0.05]. Conversely, those resin-sparse, water-rich regions degraded in the absence of biomimetic remineralization, with significant decline [p &lt; 0.05] in their complex and storage moduli (E*, 0.83 \u00b1 0.35; E\u2032\u2032, 0.88 \u00b1 0.24; E\u2032, 0.62 \u00b1 0.32). Intrafibrillar apatite deposition preserves the integrity of resin-sparse regions of hybrid layers by restoring their nanomechanical properties to those exhibited by mineralized dentin.<\/jats:p>","DOI":"10.1177\/0022034511414059","type":"journal-article","created":{"date-parts":[[2011,7,6]],"date-time":"2011-07-06T00:02:09Z","timestamp":1309910529000},"page":"1122-1128","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":80,"title":["Effect of Biomimetic Remineralization on the Dynamic Nanomechanical Properties of Dentin Hybrid Layers"],"prefix":"10.1177","volume":"90","author":[{"given":"H.","family":"Ryou","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, University of Maryland Baltimore County, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.-N.","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Stomatology, The First Hospital of Wuhan, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.R.","family":"Pucci","sequence":"additional","affiliation":[{"name":"Faculdade de Odontologia de S\u00e3o Jos\u00e9 dos Campos, UNESP, Universidade Estadual Paulista, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.D.","family":"Arola","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, University of Maryland Baltimore County, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.H.","family":"Pashley","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, School of Dentistry, Medical College of Georgia, Augusta, GA 30912, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.R.","family":"Tay","sequence":"additional","affiliation":[{"name":"Department of Endodontics, School of Dentistry, Medical College of Georgia, Augusta, GA 30912-1129, USA\r\u00a0ftay@georgiahealth.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,7,5]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1557\/jmr.2006.0257"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2003.12.012"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2009.02.001"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2911"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1021\/cg800252f"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2900"},{"key":"atypb7","first-page":"2106","volume":"21","year":"2006","journal-title":"J Mater 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