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To understand the metabolic role that saliva plays in the diseased state, we performed untargeted metabolomic profiling of saliva from healthy and periodontitic individuals. Several classes of biochemicals, including dipeptide, amino acid, carbohydrate, lipids, and nucleotide metabolites, were altered, consistent with increased macromolecular degradation of proteins, triacylglycerol, glycerolphospholipids, polysaccharides, and polynucleotides in the individuals with periodontal disease. These changes partially reflected the enhanced host-bacterial interactions in the diseased state as supported by increased levels of bacterially modified amino acids and creatine metabolite. More importantly, the increased lipase, protease, and glycosidase activities associated with periodontitis generated a more favorable energy environment for oral bacteria, potentially exacerbating the disease state.<\/jats:p>","DOI":"10.1177\/0022034511416240","type":"journal-article","created":{"date-parts":[[2011,8,19]],"date-time":"2011-08-19T22:57:50Z","timestamp":1313794670000},"page":"1293-1297","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":116,"title":["Metabolomics Reveals Elevated Macromolecular Degradation in Periodontal Disease"],"prefix":"10.1177","volume":"90","author":[{"given":"V.M.","family":"Barnes","sequence":"first","affiliation":[{"name":"Colgate-Palmolive Technology Center, 909 River Road, Piscataway, NJ 08855, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.G.","family":"Ciancio","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Endodontics, University at Buffalo, The State University of New York, School of Dental Medicine, Buffalo, NY 14214, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Shibly","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Endodontics, University at Buffalo, The State University of New York, School of Dental Medicine, Buffalo, NY 14214, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Xu","sequence":"additional","affiliation":[{"name":"Colgate-Palmolive Technology Center, 909 River Road, Piscataway, NJ 08855, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Devizio","sequence":"additional","affiliation":[{"name":"Colgate-Palmolive Technology Center, 909 River Road, Piscataway, NJ 08855, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.M.","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Colgate-Palmolive Technology Center, 909 River Road, Piscataway, NJ 08855, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Guo","sequence":"additional","affiliation":[{"name":"Metabolon Inc., 617 Davis Drive, Suite 400, Durham, NC 27713, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.J.","family":"J\u00f6nsson","sequence":"additional","affiliation":[{"name":"Metabolon Inc., 617 Davis Drive, Suite 400, Durham, NC 27713, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,8,19]]},"reference":[{"key":"bibr1-0022034511416240","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01091.x"},{"key":"bibr2-0022034511416240","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509341967"},{"key":"bibr3-0022034511416240","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100070"},{"key":"bibr4-0022034511416240","doi-asserted-by":"publisher","DOI":"10.1111\/j.1875-595X.2006.tb00110.x"},{"key":"bibr5-0022034511416240","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1384.035"},{"key":"bibr6-0022034511416240","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080233"},{"key":"bibr7-0022034511416240","unstructured":"Dabney A, Storey JD, Warnes GR (2010). q-value: q-value estimation for false discovery rate control. 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