{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:44:45Z","timestamp":1777812285352,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2011,9,22]],"date-time":"2011-09-22T00:00:00Z","timestamp":1316649600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>\n                    Based on the existing evidence supporting a state of chronic inflammation in chronic kidney disease (CKD), we hypothesized that periodontal infection may affect the systemic inflammatory status of a nationally representative CKD population as measured by serum C-reactive protein (CRP). We examined this hypothesis using the National Health and Nutrition Examination Survey 1988-1994 (NHANES III) dataset including 2303 individuals. We followed the American Academy of Periodontology (AAP)\/Centers for Disease Control and Prevention (CDC) case definition for periodontitis. We used a cutoff point of 30% sites with (PD) \u2265 5 mm and (CAL) \u2265 4 mm to define generalized periodontitis cases. We estimated glomerular filtration rate based on cystatin C levels using the relevant equation. Urinary albumin-to-creatinine ratio was calculated in milligrams per gram with a cutoff point of 30 mg\/g. CKD was defined based on eGFR &lt; 60 mL\/min\/1.73m\n                    <jats:sup>2<\/jats:sup>\n                    and albuminuria \u2265 30 mg\/g. Periodontitis was found in 427 (12.3%) individuals. Of individuals with periodontitis, 41.8% had serum CRP higher than 0.3 mg\/dL compared with 27.1% of non-periodontitis and 53.1% of edentulous individuals (p = 0.001 for all comparisons). When the extent of periodontitis was used as one of the independent variables, the parsimonious model showed a strong independent association between extent of periodontitis and serum CRP levels (OR = 2.0, CI95% = 1.2-3.6).\n                  <\/jats:p>","DOI":"10.1177\/0022034511423394","type":"journal-article","created":{"date-parts":[[2011,9,22]],"date-time":"2011-09-22T21:02:56Z","timestamp":1316725376000},"page":"1411-1415","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":46,"title":["Periodontitis Predicts Elevated C-reactive Protein Levels in Chronic Kidney Disease"],"prefix":"10.1177","volume":"90","author":[{"given":"E.","family":"Ioannidou","sequence":"first","affiliation":[{"name":"Division of Periodontology, Department of Oral Health and Diagnostic Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Swede","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Biostatistics, Department of Community Medicine and Health Care, University of Connecticut Health Center, 263 Farmington Ave., Farmington, CT 06030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Dongari-Bagtzoglou","sequence":"additional","affiliation":[{"name":"Division of Periodontology, Department of Oral Health and Diagnostic Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,9,22]]},"reference":[{"key":"bibr1-0022034511423394","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-S011"},{"key":"bibr2-0022034511423394","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2010.02317.x"},{"key":"bibr3-0022034511423394","unstructured":"CDC (2011). National Health and Nutrition Examination Survey (NHANES III). Analytic and reporting guidelines (1988-94). Hyattsville, MD: National Center for Health Statistics, Centers for Disease Control and Prevention. URL accessed August 23, 2011 at: http:\/\/www.cdc.gov\/nchs\/about\/major\/nhanes\/nh3data.htm."},{"key":"bibr4-0022034511423394","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.17.2038"},{"key":"bibr5-0022034511423394","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.8.899"},{"key":"bibr6-0022034511423394","first-page":"1","volume":"248","author":"Dye BA","year":"2007","journal-title":"Vital Health Stat 11"},{"key":"bibr7-0022034511423394","first-page":"23","volume":"2000","author":"Ebersole JL","year":"2000","journal-title":"Periodontol"},{"key":"bibr8-0022034511423394","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510377793"},{"key":"bibr9-0022034511423394","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2007.09.018"},{"key":"bibr10-0022034511423394","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.384"},{"key":"bibr11-0022034511423394","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.05.002"},{"key":"bibr12-0022034511423394","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V991689"},{"key":"bibr13-0022034511423394","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1991.120"},{"key":"bibr14-0022034511423394","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00600.x"},{"key":"bibr15-0022034511423394","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511402209"},{"key":"bibr16-0022034511423394","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.060014"},{"key":"bibr17-0022034511423394","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2004.12.009"},{"key":"bibr18-0022034511423394","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.08.041"},{"key":"bibr19-0022034511423394","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.483"},{"key":"bibr20-0022034511423394","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.38"},{"key":"bibr21-0022034511423394","volume-title":"et al","author":"Mohadjer L","year":"1996"},{"key":"bibr22-0022034511423394","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060264"},{"key":"bibr23-0022034511423394","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000052939.59093.45"},{"key":"bibr24-0022034511423394","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(03)00372-X"},{"key":"bibr25-0022034511423394","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.07839.x"},{"key":"bibr26-0022034511423394","doi-asserted-by":"publisher","DOI":"10.1177\/00220345000790010701"},{"key":"bibr27-0022034511423394","doi-asserted-by":"publisher","DOI":"10.1159\/000046932"},{"key":"bibr28-0022034511423394","doi-asserted-by":"publisher","DOI":"10.1177\/089686080102103S27"},{"key":"bibr29-0022034511423394","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2007.11.018"},{"key":"bibr30-0022034511423394","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq471"}],"container-title":["Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0022034511423394","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0022034511423394","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0022034511423394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:06:26Z","timestamp":1777496786000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0022034511423394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,22]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1177\/0022034511423394"],"URL":"https:\/\/doi.org\/10.1177\/0022034511423394","relation":{},"ISSN":["0022-0345","1544-0591"],"issn-type":[{"value":"0022-0345","type":"print"},{"value":"1544-0591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,22]]}}}