{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:01:04Z","timestamp":1790974864608,"version":"4.1.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,2,27]],"date-time":"2012-02-27T00:00:00Z","timestamp":1330300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>We have previously shown the association of AXIN2 with oral clefts in a US population. Here, we expanded our study to explore the association of 11 AXIN2 markers in 682 cleft families from multiple populations. Alleles for each AXIN2 marker were tested for transmission distortion with clefts by means of the Family-based Association Test. We observed an association with SNP rs7224837 and all clefts in the combined populations (p = 0.001), and with SNP rs3923086 and cleft lip and palate in Asian populations (p = 0.004). We confirmed our association findings in an additional 528 cleft families from the United States (p &lt; 0.009). We tested for gene-gene interaction between AXIN2 and additional cleft susceptibility loci. We assessed and detected Axin2 mRNA and protein expression during murine palatogenesis. In addition, we also observed co-localization of Axin2 with Irf6 proteins, particularly in the epithelium. Our results continue to support a role for AXIN2 in the etiology of human clefting. Additional studies should be performed to improve our understanding of the biological mechanisms linking AXIN2 to oral clefts.<\/jats:p>","DOI":"10.1177\/0022034512440578","type":"journal-article","created":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T00:40:03Z","timestamp":1330389603000},"page":"473-478","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Association of\n                    <i>AXIN2<\/i>\n                    with Non-syndromic Oral Clefts in Multiple Populations"],"prefix":"10.1177","volume":"91","author":[{"given":"A.","family":"Letra","sequence":"first","affiliation":[{"name":"School of Dentistry, University of Texas Health Science Center at Houston, DBB-202, 6516 MD Anderson Blvd., Houston, TX 77030-3402, USA"},{"name":"Pediatric Research Center, University of Texas Health Science Center at Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Bjork","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.E.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Departments of Oral Biology and Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Szabo-Rogers","sequence":"additional","affiliation":[{"name":"Department of Craniofacial Development, King\u2019s College London, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.W.B.","family":"Deleyiannis","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Otolaryngology, University of Colorado School of Medicine, Denver, CO, 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Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.M.","family":"Orioli","sequence":"additional","affiliation":[{"name":"ECLAMC (Estudo Colaborativo Latino Americano de Malforma\u00e7\u00f5es Cong\u00eanitas) at Departamento de Gen\u00e9tica, Instituto de Biologia, Rio de Janeiro, Brazil, and INAGEMP (Instituto Nacional de Gen\u00e9tica M\u00e9dica Populacional), Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Wendell","sequence":"additional","affiliation":[{"name":"Departments of Oral Biology and Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.H.","family":"Blanton","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine, Miami, FL, 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