{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:56:41Z","timestamp":1784044601307,"version":"3.55.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"7_suppl","license":[{"start":{"date-parts":[[2012,6,14]],"date-time":"2012-06-14T00:00:00Z","timestamp":1339632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p>\n                    Pathological shifts of the human microbiome are characteristic of many diseases, including chronic periodontitis. To date, there is limited evidence on host genetic risk loci associated with periodontal pathogen colonization. We conducted a genome-wide association (GWA) study among 1,020 white participants of the Atherosclerosis Risk in Communities Study, whose periodontal diagnosis ranged from healthy to severe chronic periodontitis, and for whom \u201ccheckerboard\u201d DNA-DNA hybridization quantification of 8 periodontal pathogens was performed. We examined 3 traits: \u201chigh red\u201d and \u201chigh orange\u201d bacterial complexes, and \u201chigh\u201d Aggregatibacter actinomycetemcomitans (Aa) colonization. Genotyping was performed on the Affymetrix 6.0 platform. Imputation to 2.5 million markers was based on HapMap II-CEU, and a multiple-test correction was applied (genome-wide threshold of p &lt; 5 \u00d7 10\n                    <jats:sup>\u22128<\/jats:sup>\n                    ). We detected no genome-wide significant signals. However, 13 loci, including KCNK1, FBXO38, UHRF2, IL33, RUNX2, TRPS1, CAMTA1, and VAMP3, provided suggestive evidence (p &lt; 5 \u00d7 10\n                    <jats:sup>\u22126<\/jats:sup>\n                    ) of association. All associations reported for \u201cred\u201d and \u201corange\u201d complex microbiota, but not for Aa, had the same effect direction in a second sample of 123 African-American participants. None of these polymorphisms was associated with periodontitis diagnosis. Investigations replicating these findings may lead to an improved understanding of the complex nature of host-microbiome interactions that characterizes states of health and disease.\n                  <\/jats:p>","DOI":"10.1177\/0022034512447951","type":"journal-article","created":{"date-parts":[[2012,6,14]],"date-time":"2012-06-14T14:07:10Z","timestamp":1339682830000},"page":"S21-S28","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":127,"title":["Genome-wide Association Study of Periodontal Pathogen Colonization"],"prefix":"10.1177","volume":"91","author":[{"given":"K.","family":"Divaris","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry, School of Dentistry, University of North Carolina-Chapel Hill, 228 Brauer Hall, CB#7450, NC 27599, USA"},{"name":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.L.","family":"Monda","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC, USA"},{"name":"The Center for Observational Research, Amgen Inc., Thousand Oaks, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.E.","family":"North","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC, USA"},{"name":"Carolina Center for Genome Sciences, University of North Carolina-Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.F.","family":"Olshan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.M.","family":"Lange","sequence":"additional","affiliation":[{"name":"Department of Genetics, School of Medicine, University of North Carolina-Chapel Hill, NC, USA"},{"name":"Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, NC, USA"},{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Moss","sequence":"additional","affiliation":[{"name":"Department of Dental Ecology, School of Dentistry, University of North Carolina-Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.P.","family":"Barros","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry, University of North Carolina-Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.D.","family":"Beck","sequence":"additional","affiliation":[{"name":"Department of Dental Ecology, School of Dentistry, University of North Carolina-Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Offenbacher","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry, University of North Carolina-Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,6,14]]},"reference":[{"key":"bibr1-0022034512447951","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-011-9892-7"},{"key":"bibr2-0022034512447951","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115184"},{"key":"bibr3-0022034512447951","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-11-134"},{"key":"bibr4-0022034512447951","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2009.0874"},{"key":"bibr5-0022034512447951","doi-asserted-by":"crossref","unstructured":"Badger JH, Ng PC, Venter JC (2010). 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