{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:02:43Z","timestamp":1787018563662,"version":"build-2736575974"},"reference-count":24,"publisher":"SAGE Publications","issue":"7_suppl","license":[{"start":{"date-parts":[[2012,6,14]],"date-time":"2012-06-14T00:00:00Z","timestamp":1339632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p>Human differences in disease phenotype and treatment responses are well documented. Technological advances now allow healthcare providers to improve the prevention and treatment of chronic diseases by stratifying patient populations. Although personalized medicine has great promise, it has, so far, been primarily applied in oncology. Wider adoption requires changes in the healthcare system and in clinical decision-making, and early applications of personalized medicine appear to require strong clinical utility and sufficient value to drive adoption. Personalized medicine is likely to enter dentistry as patients start to demand it and as new drugs are developed for pathways common to oral diseases.<\/jats:p>","DOI":"10.1177\/0022034512449171","type":"journal-article","created":{"date-parts":[[2012,6,14]],"date-time":"2012-06-14T14:07:10Z","timestamp":1339682830000},"page":"S8-S11","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":51,"title":["Personalized Medicine"],"prefix":"10.1177","volume":"91","author":[{"given":"K.S.","family":"Kornman","sequence":"first","affiliation":[{"name":"Interleukin Genetics, 135 Beaver Street, Suite 310, Waltham, MA 02452, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.W.","family":"Duff","sequence":"additional","affiliation":[{"name":"University of Sheffield Department of Infection and Immunity, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,6,14]]},"reference":[{"key":"bibr1-0022034512449171","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2010.0134"},{"key":"bibr2-0022034512449171","first-page":"209","volume":"20","author":"Ayhan H","year":"1996","journal-title":"J Clin Pediatr Dent"},{"issue":"4","key":"bibr3-0022034512449171","first-page":"3S","author":"Brodeur J-M","year":"2006","journal-title":"Journal de l\u2019Ordre des dentistes du Quebec"},{"key":"bibr4-0022034512449171","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.9.1707"},{"key":"bibr5-0022034512449171","first-page":"301","volume":"6","author":"Dworkin SF","year":"1992","journal-title":"J Craniomandib Disord"},{"key":"bibr6-0022034512449171","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.148015"},{"key":"bibr7-0022034512449171","unstructured":"FDA (2012). Table of Pharmacogenomic Biomarkers in Drug Labels. US Food and Drug Administration. URL accessed on 5\/1\/2012 at: http:\/\/www.fda.gov\/drugs\/scienceresearch\/researchareas\/pharmacogenetics\/ucm083378.htm."},{"key":"bibr8-0022034512449171","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)41972-6"},{"key":"bibr9-0022034512449171","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2010.05.013"},{"key":"bibr10-0022034512449171","first-page":"35","volume":"88","author":"Hildebrandt G","year":"2009","journal-title":"Northwest Dent"},{"key":"bibr11-0022034512449171","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1978.49.5.225"},{"key":"bibr12-0022034512449171","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104635"},{"key":"bibr13-0022034512449171","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb00902.x"},{"key":"bibr14-0022034512449171","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1986.tb01487.x"},{"key":"bibr15-0022034512449171","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr\/77288976"},{"key":"bibr16-0022034512449171","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032219"},{"key":"bibr17-0022034512449171","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2012.03.002"},{"key":"bibr18-0022034512449171","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2011.06.002"},{"key":"bibr19-0022034512449171","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(97)90092-5"},{"key":"bibr20-0022034512449171","doi-asserted-by":"publisher","DOI":"10.1177\/00220345950740041301"},{"key":"bibr21-0022034512449171","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2008.08.007"},{"key":"bibr22-0022034512449171","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2012.44.1.1"},{"key":"bibr23-0022034512449171","first-page":"52","volume":"12","author":"Vogel F","year":"1959","journal-title":"Ergeb Inn Med U Kinderheilk"},{"key":"bibr24-0022034512449171","doi-asserted-by":"publisher","DOI":"10.1038\/sj.tpj.6500417"}],"container-title":["Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0022034512449171","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0022034512449171","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0022034512449171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:03:25Z","timestamp":1777496605000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0022034512449171"}},"subtitle":["Will Dentistry Ride the Wave or Watch From the Beach?"],"short-title":[],"issued":{"date-parts":[[2012,6,14]]},"references-count":24,"journal-issue":{"issue":"7_suppl","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1177\/0022034512449171"],"URL":"https:\/\/doi.org\/10.1177\/0022034512449171","relation":{},"ISSN":["0022-0345","1544-0591"],"issn-type":[{"value":"0022-0345","type":"print"},{"value":"1544-0591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,14]]}}}