{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:53:00Z","timestamp":1793332380825,"version":"4.5.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2012,7,6]],"date-time":"2012-07-06T00:00:00Z","timestamp":1341532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>An extensive analysis of dental plaque samples over the years has led to the identification of \u201cred\u201d complex oral bacteria that have a strong association with each other and with disease. Consequently, these bacteria have been labeled \u2018periopathogens\u2019. Studies with one of these bacteria, Porphyromonas gingivalis, have revealed that it contains several different mechanisms which either impede or modulate periodontal protective mechanisms. In a mouse model of periodontitis, it has been shown that modulation of complement function by P. gingivalis facilitates a significant change in both the amount and composition of the normal oral microbiotia. This altered oral commensal microbiota is responsible for pathologic bone loss in the mouse. Thus, P. gingivalis creates a dysbiosis between the host and dental plaque, and this may represent one mechanism by which periodontitis can be initiated. We have therefore termed P. gingivalis a keystone pathogen.<\/jats:p>","DOI":"10.1177\/0022034512453589","type":"journal-article","created":{"date-parts":[[2012,7,6]],"date-time":"2012-07-06T21:34:45Z","timestamp":1341610485000},"page":"816-820","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":416,"title":["<i>Porphyromonas gingivalis<\/i>\n                    as a Potential Community Activist for Disease"],"prefix":"10.1177","volume":"91","author":[{"given":"R.P.","family":"Darveau","sequence":"first","affiliation":[{"name":"University of Washington, 1959 NE Pacific Street, Room D-570, UW Mailbox 357444, Seattle, WA 98195-7444, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Hajishengallis","sequence":"additional","affiliation":[{"name":"University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Curtis","sequence":"additional","affiliation":[{"name":"Barts and The London School of Medicine and Dentistry, Queen Mary University of London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,7,6]]},"reference":[{"key":"bibr1-0022034512453589","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.10.5864-5868.2000"},{"key":"bibr2-0022034512453589","doi-asserted-by":"publisher","DOI":"10.1177\/10454411010120030101"},{"key":"bibr3-0022034512453589","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.09.008"},{"key":"bibr4-0022034512453589","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.63.4.1311-1317.1995"},{"key":"bibr5-0022034512453589","first-page":"14","volume":"2000","author":"Darveau RP","year":"1997","journal-title":"Periodontol"},{"key":"bibr6-0022034512453589","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.4.1660-1665.1998"},{"key":"bibr7-0022034512453589","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2260"},{"key":"bibr8-0022034512453589","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803852105"},{"key":"bibr9-0022034512453589","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.10.006"},{"key":"bibr10-0022034512453589","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.10.7021"},{"key":"bibr11-0022034512453589","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00317-06"},{"key":"bibr12-0022034512453589","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.62.4.1244-1263.1998"},{"key":"bibr13-0022034512453589","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003252"},{"key":"bibr14-0022034512453589","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0020067"},{"key":"bibr15-0022034512453589","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2001.028006569.x"},{"key":"bibr16-0022034512453589","unstructured":"Page RC, Schroeder HE (1982). Periodontics in man and other animals, a comparative review. Basel: S. Karger Publications."},{"key":"bibr17-0022034512453589","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2007.00337.x"},{"key":"bibr18-0022034512453589","doi-asserted-by":"publisher","DOI":"10.1086\/282586"},{"key":"bibr19-0022034512453589","doi-asserted-by":"publisher","DOI":"10.2307\/1312990"},{"key":"bibr20-0022034512453589","first-page":"5","volume":"2000","author":"Socransky SS","year":"1994","journal-title":"Periodontol"},{"key":"bibr21-0022034512453589","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02419.x"},{"key":"bibr22-0022034512453589","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000697"},{"key":"bibr23-0022034512453589","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2008\/021220-0"},{"key":"bibr24-0022034512453589","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070516"}],"container-title":["Journal of Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0022034512453589","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0022034512453589","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0022034512453589","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:07:59Z","timestamp":1777496879000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0022034512453589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,6]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1177\/0022034512453589"],"URL":"https:\/\/doi.org\/10.1177\/0022034512453589","relation":{},"ISSN":["0022-0345","1544-0591"],"issn-type":[{"value":"0022-0345","type":"print"},{"value":"1544-0591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,6]]}}}