{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T10:58:22Z","timestamp":1791543502721,"version":"4.3.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2012,8,16]],"date-time":"2012-08-16T00:00:00Z","timestamp":1345075200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Adv Dent Res."],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>This is a review of the need for better remineralization and of the status of calcium-based remineralizing agents for use in anti-caries toothpastes. Use of fluoride toothpastes has markedly reduced caries. However, the decline may be over or in reverse. There is a limit to what fluoride alone can do; complementary agents are needed. Using plaque as a reservoir for calcium-based agents holds promise. Plaque fluid is already supersaturated with respect to relevant calcium phosphates at neutral pH; extra calcium may lead to surface-blocking and sub-optimal lesion consolidation. However, at cariogenic pH, lesions may be more porous to the ingress of mineral, leading to fuller consolidation, and controlled release of calcium should reduce undersaturation with respect to enamel and accelerate deposition of fluorhydroxyapatite. Clinical data to validate in vitro screening models are scarce. Direct progression to in situ models may often be appropriate. The spectrum of lesion types, from softening to relatively advanced subsurface, and lesion activity should be considered. Far from being \u2018marketing hype\u2019, progress with calcium-based remineralizing agents is both encouraging and scientifically sound. Clinical evidence exists for the efficacy of some agents, but further unequivocal clinical data are needed before these agents might be considered \u2018effective\u2019 when delivered from toothpaste.<\/jats:p>","DOI":"10.1177\/0022034512454295","type":"journal-article","created":{"date-parts":[[2012,8,16]],"date-time":"2012-08-16T11:44:28Z","timestamp":1345117468000},"page":"63-67","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":38,"title":["Remineralization Agents \u2013 New and Effective or Just Marketing Hype?"],"prefix":"10.1177","volume":"24","author":[{"given":"R.J.M.","family":"Lynch","sequence":"first","affiliation":[{"name":"GlaxoSmithKline Oral Healthcare, Weybridge, United Kingdom"},{"name":"Department of Health Services Research and School of Dentistry, University of Liverpool, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.R.","family":"Smith","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Oral Healthcare, Weybridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,8,16]]},"reference":[{"key":"bibr1-0022034512454295","first-page":"3","volume":"22","author":"Bagramian RA","year":"2009","journal-title":"Am J Dent"},{"key":"bibr2-0022034512454295","first-page":"5","volume":"9","author":"Biesbrock AR","year":"1998","journal-title":"J Clin Dent"},{"key":"bibr3-0022034512454295","doi-asserted-by":"publisher","DOI":"10.1159\/000261369"},{"key":"bibr4-0022034512454295","first-page":"S59","volume":"6","author":"Clarkson J","year":"1993","journal-title":"Am J Dent"},{"key":"bibr5-0022034512454295","doi-asserted-by":"publisher","DOI":"10.1159\/000113161"},{"key":"bibr6-0022034512454295","first-page":"1123","volume":"76","author":"Ekstrand J","year":"1984","journal-title":"Tandlakartidningen"},{"key":"bibr7-0022034512454295","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0701821104"},{"key":"bibr8-0022034512454295","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1992.tb01693.x"},{"key":"bibr9-0022034512454295","first-page":"185","volume":"22","author":"Karlinsey RL","year":"2009","journal-title":"Am J Dent"},{"key":"bibr10-0022034512454295","doi-asserted-by":"publisher","DOI":"10.1159\/000323846"},{"key":"bibr11-0022034512454295","doi-asserted-by":"publisher","DOI":"10.1111\/j.1875-595X.2004.tb00004.x"},{"key":"bibr12-0022034512454295","doi-asserted-by":"publisher","DOI":"10.1159\/000095653"},{"key":"bibr13-0022034512454295","doi-asserted-by":"publisher","DOI":"10.1159\/000095652"},{"key":"bibr14-0022034512454295","doi-asserted-by":"publisher","DOI":"10.1159\/000260677"},{"key":"bibr15-0022034512454295","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjm008"},{"key":"bibr16-0022034512454295","doi-asserted-by":"publisher","DOI":"10.1159\/000261411"},{"key":"bibr17-0022034512454295","doi-asserted-by":"publisher","DOI":"10.1038\/247064a0"},{"key":"bibr18-0022034512454295","doi-asserted-by":"publisher","DOI":"10.1177\/0895937409335619"},{"key":"bibr19-0022034512454295","doi-asserted-by":"publisher","DOI":"10.1007\/BF03262674"},{"key":"bibr20-0022034512454295","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(00)00017-0"},{"key":"bibr21-0022034512454295","doi-asserted-by":"publisher","DOI":"10.1159\/000262360"},{"key":"bibr22-0022034512454295","doi-asserted-by":"publisher","DOI":"10.1002\/idj.2009.59.6s1.321"},{"key":"bibr23-0022034512454295","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60031-2"},{"key":"bibr24-0022034512454295","doi-asserted-by":"publisher","DOI":"10.1159\/000260477"},{"key":"bibr25-0022034512454295","first-page":"49","volume-title":"Dental caries","author":"ten Cate JM","year":"2004"},{"key":"bibr26-0022034512454295","doi-asserted-by":"publisher","DOI":"10.1159\/000224210"},{"key":"bibr27-0022034512454295","doi-asserted-by":"publisher","DOI":"10.1159\/000325166"},{"key":"bibr28-0022034512454295","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508400510"},{"key":"bibr29-0022034512454295","doi-asserted-by":"publisher","DOI":"10.1159\/000063931"},{"key":"bibr30-0022034512454295","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6831-6-S1-S9"}],"container-title":["Advances in Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0022034512454295","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0022034512454295","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0022034512454295","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:42:57Z","timestamp":1777398177000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0022034512454295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,16]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1177\/0022034512454295"],"URL":"https:\/\/doi.org\/10.1177\/0022034512454295","relation":{},"ISSN":["0895-9374","1544-0737"],"issn-type":[{"value":"0895-9374","type":"print"},{"value":"1544-0737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,16]]}}}