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Several methods have been proposed and demonstrated for creating nanotopographic features; here we describe a nanoscale hydroxyapatite (HA)-coated implant surface and hypothesize that it will hasten osseointegration and improve its quality relative to that of non-coated implants. Twenty threaded titanium alloy implants, half prepared with a stable HA nanoparticle surface and half grit-blasted, acid-etched, and heat-treated (HT), were inserted into rabbit femurs. Pre-operatively, the implants were morphologically and topographically characterized. After 3 weeks of healing, the samples were retrieved for histomorphometry. The nanomechanical properties of the surrounding bone were evaluated by nanoindentation. While both implants revealed similar bone-to-implant contact, the nanoindentation demonstrated that the tissue quality was significantly enhanced around the HA-coated implants, validating the postulated hypothesis.<\/jats:p>","DOI":"10.1177\/0022034512463240","type":"journal-article","created":{"date-parts":[[2012,10,9]],"date-time":"2012-10-09T01:27:31Z","timestamp":1349746051000},"page":"1172-1177","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":94,"title":["Nano Hydroxyapatite-coated Implants Improve Bone Nanomechanical Properties"],"prefix":"10.1177","volume":"91","author":[{"given":"R.","family":"Jimbo","sequence":"first","affiliation":[{"name":"Department of Prosthodontics, Faculty of Odontology, Malm\u00f6 University, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.G.","family":"Coelho","sequence":"additional","affiliation":[{"name":"Department of Biomaterials and Biomimetics, New York University, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bryington","sequence":"additional","affiliation":[{"name":"Division of Restorative and Prosthetic Dentistry, The Ohio State University College of Dentistry, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Baldassarri","sequence":"additional","affiliation":[{"name":"Department of Biomaterials and Biomimetics, New York University, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Tovar","sequence":"additional","affiliation":[{"name":"Department of Biomaterials and Biomimetics, New York University, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Currie","sequence":"additional","affiliation":[{"name":"Promimic AB, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Faculty of Odontology, Malm\u00f6 University, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.N.","family":"Janal","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Promotion, New York University College of Dentistry, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering, Applied Surface Chemistry, Chalmers University of Technology, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Ono","sequence":"additional","affiliation":[{"name":"Division of Applied Prosthodontics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Vandeweghe","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Faculty of Odontology, Malm\u00f6 University, Sweden"},{"name":"Department of Periodontology and Oral Implantology, Dental School, Faculty of Medicine and Health Sciences, University of Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Wennerberg","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Faculty of Odontology, Malm\u00f6 University, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,10,8]]},"reference":[{"key":"bibr1-0022034512463240","unstructured":"Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P (2002). 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